{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:16:46Z","timestamp":1791238606956,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n                    Purslane (\n                    <jats:italic>Portulaca oleracea<\/jats:italic>\n                    L.) is the richest green leafy vegetable source of omega\u20103, especially alpha linolenic acid (ALA). Experimental studies have shown beneficial effects of purslane extract on liver enzymes. The aim of the present study was to examine the effect of purslane hydroalcohoic extract in patients with non\u2010alcoholic fatty liver disease (NAFLD). In a randomized double\u2010blinded clinical trial, 74 patients were randomly assigned to receive either 300\u2009mg purslane extract or placebo capsules for 12\u2009weeks. Compared with baseline, alanine aminotransferase (ALT) (\u22129 [\u221217, 0.50] mg\/dl;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.007), aspartate aminotransferase (AST) (\u22124 [\u221210, \u22120.50] mg\/dl;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.001), gamma glutamyltransferase (GGT) (\u22126.21\u2009\u00b1\u20099.85\u2009mg\/dL;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), fasting blood glucose (FBG) (\u22128 [\u221211, \u22121.50] mg\/dl;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001) insulin resistance (\u22120.95\u2009\u00b1\u20092.23;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.020), triglyceride (\u221220 [\u221267.50, 3.50] mg\/dl;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.010), and low\u2010density lipoprotein cholesterol (LDL\u2010C) (\u22125 [\u221212, \u22121] mg\/dl;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001) decreased significantly in the purslane group. At the end of study, no significant changes were observed in liver steatosis grade, insulin, liver enzymes, total bilirubin, lipid profile, and blood pressure between the two groups. The findings of our study show that purslane extract at the dose of 300\u2009mg\/day for 12\u2009weeks has no significant effects on liver enzymes, lipid profile, and glycemic indices in patients with NAFLD.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6972","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T18:35:41Z","timestamp":1619030141000},"page":"3145-3156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Effect of\n                    <i>Portulaca Oleracea<\/i>\n                    (purslane) extract on liver enzymes, lipid profile, and glycemic status in nonalcoholic fatty liver disease: A randomized, double\u2010blind clinical trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Reyhaneh","family":"Darvish Damavandi","sequence":"first","affiliation":[{"name":"Department of Nutrition School of Public Health, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-9253","authenticated-orcid":false,"given":"Farzad","family":"Shidfar","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health, Iran University of Medical Sciences  Tehran Iran"},{"name":"Colorectal Research Center, Rasoul\u2010e\u2010Akram Hospital, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Medical Sciences, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Janani","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Masoodi","sequence":"additional","affiliation":[{"name":"Colorectal Research Center, Rasoul\u2010e\u2010Akram Hospital, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Akbari\u2010Fakhrabadi","sequence":"additional","affiliation":[{"name":"Department of Applied Human Nutrition Mount Saint Vincent University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Dehnad","sequence":"additional","affiliation":[{"name":"School of Health Management and Information Sciences, Department of Medical Education Center for Educational Research in Medical Sciences (CERMS), Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2014.926040"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"163","article-title":"The effect of purslane seeds on fasting blood glucose and serum liver enzymes in patients with nonalcoholic fatty livers","volume":"7","author":"Adelnia Najafabadi E.","year":"2015","journal-title":"Iranian Journal of Diabetes and Obesity"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2919"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2018.24"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/296063"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.84973"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081201"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3038"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512001584"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00786-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuv048"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37819"},{"issue":"9","key":"e_1_2_8_15_1","first-page":"1589","article-title":"Antioxidant effect of purslane (Portulaca oleracea) and its mechanism of action","volume":"5","author":"Dkhil M. A.","year":"2011","journal-title":"Journal of Medicne Plants Research"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.957783"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020802320590"},{"issue":"10","key":"e_1_2_8_18_1","first-page":"2075","article-title":"Effects of flavonoid\u2010rich fruits on hypertension in adults: A systematic review","volume":"17","author":"Ellwood L.","year":"2019","journal-title":"JBI Evidence Synthesis"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.06.020"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2018.1479990"},{"issue":"1","key":"e_1_2_8_21_1","first-page":"47","article-title":"The effect of purslane seeds on glycemic status and lipid profiles of persons with type 2 diabetes: A randomized controlled cross\u2010over clinical trial","volume":"20","author":"Esmaillzadeh A.","year":"2015","journal-title":"Journal of Research in Medical Sciences"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.09.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2010.09.035"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.5.1141"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6342"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10030880"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/48.8.663"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6203"},{"issue":"1","key":"e_1_2_8_29_1","first-page":"582","article-title":"Purslane effect on GLP\u20101 and GLP\u20101 receptor in type 2 diabetes","volume":"5","author":"Heidarzadeh S.","year":"2013","journal-title":"Electronic Physician"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.113"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.12991\/mpj.2017.9"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29222-y"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55050166"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_114_19"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.108.000604"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.2248"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02838618"},{"key":"e_1_2_8_38_1","first-page":"2012","article-title":"Portulaca oleracea ameliorates diabetic vascular inflammation and endothelial dysfunction in db\/db mice","volume":"741824","author":"Lee A. S.","year":"2012","journal-title":"Evidence\u2010Based Complementary and Alternative Medicine"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112973"},{"issue":"3","key":"e_1_2_8_40_1","first-page":"202","article-title":"Effects of Portulaca oleracea powder on the lipid levels of rats fed a hypercholesterolemia inducing diet","volume":"16","author":"Lee S.\u2010J.","year":"2011","journal-title":"Journal of Food Science and Nutrition"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-011-1572-z"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.06.034"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i32.7236"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu024"},{"issue":"3","key":"e_1_2_8_45_1","first-page":"149","article-title":"Prevalence of non\u2010alcoholic fatty liver disease and its related factors in Iran","volume":"7","author":"Moghaddasifar I.","year":"2016","journal-title":"International Journal of Organ Transplant Medicine"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2007.285.289"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2016.1267597"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.126621"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1651330"},{"key":"e_1_2_8_50_1","first-page":"329","article-title":"Effects of consuming purslane seed powder on indicators of metabolic syndrome in women: A randomized clinical trial","volume":"21","author":"Papoli M.","year":"2019","journal-title":"Progress in Nutrition"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2018.12.3.183"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.4098"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i25.2597"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5659"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1530-1"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2014.68.195-199"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.15171\/jhp.2018.02"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1503"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2298"},{"issue":"6","key":"e_1_2_8_60_1","first-page":"746","article-title":"Ethanol extract of Portulaca oleracea L. reduced the carbon tetrachloride induced liver injury in mice involving enhancement of NF\u2010kappaB activity","volume":"6","author":"Shi H.","year":"2014","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_8_61_1","first-page":"39","article-title":"Portulaca oleracea L.(purslane) extracts display antioxidant and hypoglycaemic effects","volume":"91","author":"Sicari V.","year":"2018","journal-title":"Journal of Applied Botany Food Quality"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1992.10718240"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/951019"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.30121"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2015.0090"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-015-0082-6"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2016.1161011"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(01)00053-9"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28785"},{"key":"e_1_2_8_71_1","first-page":"1","article-title":"Effects of alpha\u2010linolenic acid intake on blood lipid profilesa systematic review and meta\u2010analysis of randomized controlled trials","author":"Yue H.","year":"2020","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200400045"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000758"},{"issue":"4","key":"e_1_2_8_74_1","first-page":"290","article-title":"Hypoglycemic and hypolipidemic effects of flavonoids from lotus (Nelumbo nuficera Gaertn) leaf in diabetic mice","volume":"3","author":"Zhou T.","year":"2009","journal-title":"Journal of Medicinal Plant Research"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/925631"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.6972","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T06:12:50Z","timestamp":1745993570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,20]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ptr.6972"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6972","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,20]]},"assertion":[{"value":"2020-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}