{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T16:16:21Z","timestamp":1764519381226,"version":"3.40.5"},"reference-count":79,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>At present, googling the search terms \u201cCOVID\u201019\u201d and \u201cFunctional foods\u201d yields nearly 500,000,000 hits, witnessing the growing interest of the scientific community and the general public in the role of nutrition and nutraceuticals during the COVID\u201019 pandemic. Many compounds have been proposed as phytotherapics in the prevention and\/or treatment of COVID\u201019. The extensive interest of the general public and the enormous social media coverage on this topic urges the scientific community to address the question of whether which nutraceuticals can actually be employed in preventing and treating this newly described coronavirus\u2010related disease. Recently, the Canadian biotech pharma company \u201cFSD Pharma\u201d received the green light from the Food and Drug Administration to design a proof\u2010of\u2010concept study evaluating the effects of ultramicronized palmitoylethanolamide (PEA) in COVID\u201019 patients. The story of PEA as a nutraceutical to prevent and treat infectious diseases dates back to the 1970s where the molecule was branded under the name Impulsin and was used for its immunomodulatory properties in influenza virus infection. The present paper aims at analyzing the potential of PEA as a nutraceutical and the previous evidence suggesting its anti\u2010inflammatory and immunomodulatory properties in infectious and respiratory diseases and how these could translate to COVID\u201019 care.<\/jats:p>","DOI":"10.1002\/ptr.6978","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T17:21:37Z","timestamp":1607620897000},"page":"2514-2522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Phytotherapics in <scp>COVID19<\/scp>: Why palmitoylethanolamide?"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5996-4259","authenticated-orcid":false,"given":"Marcella","family":"Pesce","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery University of Naples \"Federico II\"  Naples 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