{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:55:22Z","timestamp":1781787322701,"version":"3.54.5"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This systematic review and meta\u2010analysis were performed to investigate the efficacy and safety of <jats:italic>Tripterygium wilfordii<\/jats:italic> glycosides (TG) for rheumatoid arthritis (RA) from the current literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic search was conducted in eight databases (PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese VIP Database, and Wanfang Database) from inception until September 2020. Randomized controlled trials (RCTs) with risk of bias (RoB) score \u2265\u20094 according to the Cochrane RoB tool were included for the analyses. The primary outcome measures were duration of morning stiffness (DMS), tender joint count (TJC), swollen joint count (SJC), visual analog score (VAS), C\u2010reactive protein (CRP), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF). The secondary outcome measures were the total clinical effective rate and adverse events. All the analyses were used by the random effects models. The meta\u2010analysis was performed using RevMan 5.3 and STATA 14.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 40 RCTs with 3092 patients met our inclusion criteria. This meta\u2010analysis showed that TG plus DMARDs for RA could decrease the DMS (<jats:italic>p<\/jats:italic> &lt; .001), TJC (<jats:italic>p<\/jats:italic> &lt; .001), SJC (<jats:italic>p<\/jats:italic> &lt; .001), VAS (<jats:italic>p<\/jats:italic> &lt; .001), serum CRP (<jats:italic>p<\/jats:italic> &lt; .001), ESR (<jats:italic>p<\/jats:italic> &lt; .001), and RF (<jats:italic>p<\/jats:italic> &lt; .001) and improve total effective rate (<jats:italic>p<\/jats:italic> &lt; .001). In addition, TG was generally safe and well tolerated in RA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the limitations, the present evidence supports, at least to an extent, that TG can be recommended for routine use for RA patients. More large multicenter and high\u2010quality RCTs are required for further research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ptr.6996","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T03:14:10Z","timestamp":1608866050000},"page":"2902-2924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The effectiveness and safety of <i>Tripterygium wilfordii<\/i> glycosides combined with disease\u2010modifying anti\u2010rheumatic drugs in the treatment of rheumatoid arthritis: A systematic review and meta\u2010analysis of 40 randomized controlled trials"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-2456","authenticated-orcid":false,"given":"Wenhao","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 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