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Emerging studies from bench to bedside have demonstrated the pivotal role of low\u2010density lipoprotein (LDL) oxidation in the initiation and progression of atherosclerosis. This article hereby reviews oxidation mechanism of LDL, and the pro\u2010atherogenic and biomarker role of oxidized LDL in atherosclerosis. We also review the pharmacological effects of several representative natural products (vitamin E, resveratrol, quercetin, probucol, tanshinone IIA, epigallocatechin gallate, and Lycopene) in protecting against LDL oxidation and atherosclerosis. Clinical and basic research supports the beneficial effects of these natural products in inhibiting LDL oxidation and preventing atherosclerosis, but the data are still controversial. This may be related to factors such as the population and the dosage and time of taking natural products involved in different studies. Understanding the mechanism of LDL oxidation and effect of oxidized LDL help researchers to find novel therapies against atherosclerosis.<\/jats:p>","DOI":"10.1002\/ptr.7002","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T05:30:18Z","timestamp":1608960618000},"page":"2945-2967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Natural products: The role and mechanism in low\u2010density lipoprotein oxidation and atherosclerosis"],"prefix":"10.1002","volume":"35","author":[{"given":"Shengyu","family":"Zhang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Anhui Provincial Hospital Anhui 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