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Although antibiotic\u2010based regimens are the current therapeutic mainstay, their clinical utility is increasingly constrained by rising resistance rates, treatment\u2010associated adverse effects, and incomplete eradication efficacy. Natural products, particularly plant\u2010derived bioactive compounds, have emerged as a promising reservoir for anti\u2010<jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> drug discovery, demonstrating multifaceted mechanisms ranging from direct bactericidal activity to virulence factor suppression. However, to date, no phytochemical compounds have been successfully developed into antibacterial drugs, though accumulating preclinical evidence highlights their translational potential. This review systematically evaluates the epidemiological characteristics and clinical impacts of <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection, as well as the therapeutic limitations of current eradication regimens. Furthermore, it emphasizes the current status, underlying mechanisms, and challenges of natural products in the treatment of <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>. We aim to gain deeper insights into the medicinal value of natural products, thereby providing valuable references for the development of novel drugs targeting <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection and evidence\u2010based antimicrobial treatment.<\/jats:p>","DOI":"10.1002\/ptr.70031","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:39:27Z","timestamp":1754984367000},"page":"4282-4307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Compounds of Plant Origin: The Blue Ocean of Anti\u2010<scp><i>Helicobacter pylori<\/i><\/scp> Medicines"],"prefix":"10.1002","volume":"39","author":[{"given":"Huimin","family":"Wu","sequence":"first","affiliation":[{"name":"Engineering Research Center of Coptis Development and Utilization (Ministry of Education) College of Pharmaceutical Sciences, Southwest University  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