{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:55:25Z","timestamp":1793746525184,"version":"4.6.1"},"reference-count":64,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873069"],"award-info":[{"award-number":["81873069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The increasing rates of drug resistance in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    <\/jats:styled-content>\n                    (Mtb) have made controlling tuberculosis more challenging. Excessive programmed cell death helps mediate Mtb transmission. Salvianolic acid B (Sal B), a water\u2010soluble extract of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    <\/jats:styled-content>\n                    , has been reported to inhibit programmed cell death and excessive inflammation. This study aimed to investigate the potential inhibitory mechanism of Sal B on PANoptosis. The inhibitory effect of Sal B on PANoptosis was evaluated by western blotting, ELISA, and other techniques in an in\u00a0vitro model of Mtb H37Ra\u2010infected macrophages. The roles of ZBP1 and TNFR1 in PANoptosis were explored by small interfering RNA transfection. In addition, the inhibitory effect of Sal B on PANoptosis and the hyperinflammatory response was verified by western blotting, hematoxylin and eosin staining, and immunohistochemistry in an in\u00a0vivo model of inflammatory injury in the lungs of LPS\u2010infected mice. Sal B inhibited the protein levels of key molecules of Mtb\u2010mediated PANoptosis and hindered the assembly of the PANoptosome consisting of ASC, ZBP1, RIPK1, RIPK3, and Caspase 8. Sal B may further inhibit PANoptosis by binding to TNFR1 and suppressing ZBP1 levels. In addition, the results of in\u00a0vivo studies verified that Sal B could ameliorate LPS\u2010induced pathological injury in mouse lung tissues. Sal B can target TNFR1 to achieve a regulatory effect on macrophage PANoptosis. This provides new ideas for Sal B as a host\u2010directed therapy drug to attenuate the excessive inflammatory response induced by Mtb infection.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70042","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T02:33:32Z","timestamp":1753670012000},"page":"4028-4045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Salvianolic Acid B Inhibits\n                    <scp>ZBP1<\/scp>\n                    \u2010Mediated\n                    <scp>PANoptosis<\/scp>\n                    in\n                    <scp>\n                      <i>Mycobacterium tuberculosis<\/i>\n                    <\/scp>\n                    \u2010Infected Macrophages by Targeting\n                    <scp>TNFR1<\/scp>"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-9629","authenticated-orcid":false,"given":"Jingjing","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Immunology and Pathogenic Biology, Center for Traditional Chinese Medicine and Immunology Research, School of Integrative Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Department of Infectious Diseases First Affiliated Hospital of Bengbu Medical College  Bengbu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogenic Biology, Center for Traditional Chinese Medicine and Immunology Research, School of Integrative Medicine Shanghai University of Traditional Chinese Medicine  Shanghai 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