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However, evidence regarding their therapeutic effects and safety for weight loss remains limited. Thefore, this study aimed to identify herbal medicines used for weight loss and their efficacy and safety. A scoping review was conducted using PubMed, Embase, Scopus, and LILACS databases (September 2023). Studies evaluating the efficacy and safety of herbal medicines for weight loss in individuals aged 18\u2009years or older were included. Study selection and data extraction were performed independently by two reviewers. A total of 74 studies involving 5508 participants were included. Most studies were double\u2010blind randomized clinical trials (<jats:italic>n<\/jats:italic>\u2009=\u200950) and conducted in participants diagnosed with overweight and\/or obesity (<jats:italic>n<\/jats:italic>\u2009=\u200970), predominantly in Asia (<jats:italic>n<\/jats:italic>\u2009=\u200940). The duration of interventions ranged from 10 to 613\u2009days. The most frequently evaluated herbal medicines were <jats:styled-content style=\"fixed-case\">\n<jats:italic>Camellia sinensis<\/jats:italic>\n<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200916), <jats:italic>Ephedra<\/jats:italic> sp. (<jats:italic>n<\/jats:italic>\u2009=\u200913), <jats:italic>Garcinia cambogia<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20099), <jats:italic>Citrus<\/jats:italic> sp. (<jats:italic>n<\/jats:italic>\u2009=\u20095), and <jats:italic>Glycyrrhiza<\/jats:italic> sp. (<jats:italic>n<\/jats:italic>\u2009=\u20095). Five studies conducted post\u2010intervention follow\u2010ups. Only 10 studies did not report improvements in any parameter. Adverse events ranged from mild symptoms (e.g., headache) to severe reactions (e.g., increased blood pressure), with <jats:italic>Ephedra<\/jats:italic> sp. being linked to the most serious events. In conclusion, herbal medicinal products may offer benefits for weight loss. 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