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Acting through potent antioxidant, anti\u2010inflammatory, anti\u2010apoptotic, and metabolic regulatory mechanisms, quercetin modulates key molecular pathways implicated in age\u2010related disorders across multiple systems, including the cardiovascular, skeletal, neurological, metabolic, and ocular domains. This review synthesizes these shared mechanisms to support a systems\u2010level perspective on quercetin's therapeutic potential. By influencing these signaling cascades, quercetin exerts protective effects across a range of aging\u2010associated disorders, namely cardiovascular diseases, osteoporosis, cerebrovascular accidents, diabetes, dementia, and eye\u2010related diseases. This review is based on a comprehensive literature search conducted in PubMed, Scopus, and Web of Science up to March 2025, using keywords related to quercetin, polyphenols, aging, and associated diseases. 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