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Their complex molecular structures confer a wide range of pharmacological activities, including antioxidant effects through reactive oxygen species (ROS) scavenging and Nrf2 activation, anti\u2010inflammatory properties via NF\u2010\u03baB inhibition, anti\u2010apoptotic effects, and modulation of ion channel activities. These mechanisms make flavonoids promising candidates for therapeutic applications across various conditions, including neurological disorders, cardiovascular diseases, cancer, and metabolic disorders. Specifically, inflammation and ion channel dysfunction are common underlying factors in many diseases, positioning flavonoids as potential multi\u2010target interventions. For instance, apigenin and vitexin are natural, safe alternatives for treating neuroinflammatory conditions such as multiple sclerosis, offering efficacy with minimal side effects. This review categorizes flavonoids based on their structural characteristics and explores their advancements in addressing inflammation, oxidative stress, apoptosis, ion channel regulation, pain relief, and neurological disorders, including epilepsy, Alzheimer's disease, Parkinson's disease, and anti\u2010stroke. Ultimately, the review underscores the need for further high\u2010quality studies to firmly establish the clinical efficacy of these plant\u2010derived compounds, alongside research into optimal dosing and formulation strategies, highlighting their potential as multi\u2010faceted therapeutic agents for neurological disorders.<\/jats:p>","DOI":"10.1002\/ptr.70097","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T03:59:56Z","timestamp":1759377596000},"page":"5222-5248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacological Diversity of Flavonoids and Their Clinical Application Prospects in Neurological Disorders"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6586-6022","authenticated-orcid":false,"given":"Shuai","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Hebei University  Baoding 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