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To investigate the effect and possible mechanism of CUR on GPL both in\u00a0vitro and in\u00a0vivo, an N\u2010methyl\u2010N'\u2010nitro\u2010N\u2010nitrosoguanidine (MNNG)\u2010induced rat model of GPL and a malignant transformation model of human gastric epithelial cells (MC cells) were employed. The results showed that CUR treatment reversed intestinal metaplasia and dysplasia in GPL rats. Furthermore, CUR treatment led to decreased levels of gastrin 17 and increased levels of pepsinogen I (PG I) and prostaglandin E2 (PGE2) in the rat model. Compared to normal controls, GPL rats exhibited elevated levels of interleukin 1\u03b2 (IL\u20101\u03b2), IL\u20104, IL\u20106, tumor necrosis factor \u03b1 (TNF\u2010\u03b1), and interferon\u2010\u03b3 (IFN\u2010\u03b3), along with decreased levels of IL\u201010. CUR treatment reduced the levels of IL\u20101\u03b2 and IL\u20104. Immunohistochemical analysis revealed that protein expressions of Yes\u2010associated protein 1 (YAP1) and TEA domain transcription factor 1 (TEAD1) were significantly upregulated in human GPL tissues, while p\u2010YAP1 expression was downregulated. CUR treatment downregulated YAP1 and TEAD1, and upregulated p\u2010YAP1 and apoptosis\u2010related proteins both in\u00a0vivo and in\u00a0vitro. In conclusion, CUR could alleviate gastric mucosal inflammation and prevent the occurrence and progression of GPL, potentially via modulation of the YAP\/TEAD axis in the Hippo signaling pathway.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70127","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:34:20Z","timestamp":1767720860000},"page":"737-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Curcumin Alleviates Gastric Precancerous Lesions by Modulating\n                    <scp>YAP<\/scp>\n                    \/\n                    <scp>TEAD<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5860-3790","authenticated-orcid":false,"given":"Jinhao","family":"Zeng","sequence":"first","affiliation":[{"name":"TCM Prevention and Treatment of Metabolic and Chronic Diseases Key Laboratory of 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