{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:58:43Z","timestamp":1785855523914,"version":"3.56.0"},"reference-count":114,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Reproductive health is a major component of overall well\u2010being, which is regulated by various factors like nutrition, stress and lifestyle; all of these in turn influence fertility and sexual function. Ideal reproductive health requires constant upkeep in individuals of both males and females, with natural products like ashwagandha gaining significant attention for their potential advantages. Various studies are exploring the effect of ashwagandha in the reproductive systems of both males and females. These studies are emphasizing some specific parameters like polycystic ovary syndrome, stress\u2010induced menstrual irregularities in the case of the female reproductive system and sperm count and quality in the case of the male reproductive system. In order to study the impact of ashwagandha on the reproductive system, we conducted a systematic review involving a search of major databases like MEDLINE\/PubMed, Web of Science, Scopus, Science Direct, and Google Scholar, following PRISMA guidelines. Our review included a detailed analysis of preclinical and clinical research articles that evaluated the role of ashwagandha in improving reproductive health and sexual dysfunction. This study specifically looked at its impact on the reproductive system. The findings of this study indicate that ashwagandha has the potential to improve sexual health. It can also serve as a therapeutic agent in certain reproductive disorders due to its antioxidant nature. In conclusion, ashwagandha appears to be a promising natural adjunct to the enhancement of reproductive health; however, more study is needed to understand its long\u2010term effects and dosing more fully.<\/jats:p>","DOI":"10.1002\/ptr.70128","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T02:10:16Z","timestamp":1763431816000},"page":"4813-4832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Ashwagandha on Reproductive Health: A Systematic Review of Sex\u2010Specific Hormonal and Fertility Outcomes"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7273-3455","authenticated-orcid":false,"given":"Debajyoti","family":"Roy","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy CV Raman Global University  Bhubaneswar Odisha India"},{"name":"Department of Pharmacognosy Institute of Pharmacy, Nirma University  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7657-0805","authenticated-orcid":false,"given":"Maitrayee","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Amity Institute of Pharmacy, Amity University Uttar Pradesh  Noida Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipan","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology Birla Institute of Technology  Ranchi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Amity Institute of Pharmacy, Amity University Uttar Pradesh  Noida Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-8749","authenticated-orcid":false,"given":"Rohit","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University  Rajpura Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-4710","authenticated-orcid":false,"given":"Naresh Kumar","family":"Rangra","sequence":"additional","affiliation":[{"name":"Chitkara University School of Pharmacy, Chitkara University  Himachal Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/revac-2022-0055"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.04.046"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517752022"},{"issue":"10","key":"e_1_2_10_5_1","article-title":"Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo\u2010Controlled Study","volume":"14","author":"Ajgaonkar A.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/571420"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2024.103062"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271221106344"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13041"},{"issue":"1","key":"e_1_2_10_10_1","article-title":"Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence","volume":"2018","author":"Azgomi R. 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