{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:59:27Z","timestamp":1791572367276,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304807"],"award-info":[{"award-number":["82304807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220299"],"award-info":[{"award-number":["BK20220299"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ulcerative colitis (UC) is a chronic inflammatory disease of the colon, characterized by recurrent flare\u2010ups and limited effectiveness of available drug therapies. Asiatic acid (AA), a triterpenoid compound extracted from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Centella asiatica<\/jats:italic>\n                    <\/jats:styled-content>\n                    , has shown promising pharmacological activities and therapeutic potential in several inflammation\u2010related diseases. However, AA's efficacy in treating UC and its precise mechanisms of action remain to be fully explored. This study aimed to provide a comprehensive assessment of AA's therapeutic effects on UC and to investigate its underlying mechanisms, with a focus on gut microbiota interactions. In our study, a dextran sulfate sodium\u2010induced UC mouse model was used to evaluate AA's therapeutic potential and explore its impact on gut microbiota composition and function. We further used an antibiotic cocktail and fecal microbiota transplantation assays to substantiate the role of gut microbiota in AA's mechanisms of action. A metabolomic analysis was also conducted to identify key metabolic pathways and gut microbiota\u2010derived metabolites involved in AA's effects. Our findings demonstrated that AA significantly alleviates symptoms of UC, including reducing weight loss, slowing disease progression, mitigating colonic inflammation, and restoring immune balance. Mechanistically, the beneficial effects of AA were strongly linked to alterations in the gut microbiota and its metabolites, particularly \u03b3\u2010glutamyltyrosine. This metabolite was found to regulate the cyclic adenosine monophosphate\/protein kinase A\/nuclear factor kappa\u2010B signaling pathway, which plays a crucial role in inflammatory responses. Overall, these findings strongly suggest that AA holds promise as a therapeutic agent for UC by modulating the gut microbiota and influencing critical inflammatory pathways.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70132","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T09:10:55Z","timestamp":1763975455000},"page":"267-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Asiatic Acid Alleviates Ulcerative Colitis Through a Gut Microbiota\u2010Driven\n                    <scp>cAMP<\/scp>\n                    \/\n                    <scp>PKA<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Pathway:\n                    <scp>\u03b3\u2010Glutamyltyrosine<\/scp>\n                    Is a Crucial Player"],"prefix":"10.1002","volume":"40","author":[{"given":"Xian","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pharmacy Affiliated Kunshan Hospital of Jiangsu University  Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology Kunshan Hospital of Traditional Chinese Medicine  Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Affiliated Kunshan Hospital of Jiangsu University  Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kekang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Affiliated Kunshan Hospital of Jiangsu University  Kunshan 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