{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:05:51Z","timestamp":1787166351607,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20230203184SF"],"award-info":[{"award-number":["20230203184SF"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970576"],"award-info":[{"award-number":["81970576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Liver fibrosis is an increasingly serious global health issue, and an effective treatment strategy is to inhibit the activation of hepatic stellate cells (HSCs). The role of daphnetin (Daph), which is a natural coumarin derivative isolated from plants of the genus Daphne, in the treatment of hepatic fibrosis is still unclear. Mice were treated with carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ), and the inhibitory effect of Daph on hepatic fibrosis was evaluated. In\u00a0vitro, the effect of Daph on the activated human HSCs line LX\u20102 was studied. In\u00a0vivo, Daph alleviated collagen accumulation and reduced the expression of fibrotic genes. However, these changes were reversed with ferrostatin\u20101 (Fer\u20101). In\u00a0vitro, Daph induced ferroptosis in LX\u20102 cells, which was characterized by increased lipid peroxidation and iron accumulation. However, deferoxamine (DFO) and Fer\u20101 partially abrogated the antifibrotic effect of Daph. Mechanically, Daph exerted an antifibrotic effect by ubiquitinating glutathione peroxidase 4 (GPX4) and stimulating ferritinophagy\u2010mediated ferroptosis in HSCs. These results indicated that Daph promoted the ubiquitination of GPX4 and ferritinophagy\u2010mediated ferroptosis in HSCs, which could provide new clues for further pharmacological research on the antifibrotic effect of Daph.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70134","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T06:18:46Z","timestamp":1765001926000},"page":"473-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Daphnetin Alleviates Liver Fibrosis by Inducing Ferritinophagy\u2010Mediated Ferroptosis in Activated Hepatic Stellate Cells"],"prefix":"10.1002","volume":"40","author":[{"given":"Laiyu","family":"Zhu","sequence":"first","affiliation":[{"name":"Institute of Liver Diseases The First Hospital of Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Women's Reproductive Health The First Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Liver Diseases The First Hospital of Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Women's Reproductive Health The First Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainan","family":"Chang","sequence":"additional","affiliation":[{"name":"Central Sterile Supply Department The First Hospital of Jilin University  Changhun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2207-6869","authenticated-orcid":false,"given":"Xinxin","family":"Ci","sequence":"additional","affiliation":[{"name":"Institute of Liver Diseases The First Hospital of Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Women's Reproductive Health The First Hospital of Jilin 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