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Cancer stem cells (CSCs) are the major source of occurrence and progression of PC, suggesting that targeting pancreatic CSC stemness may provide therapeutic benefits. This study aims to clarify the mechanisms by which Honokiol (HNK) inhibits the stemness of pancreatic cancer. The expression of c\u2010Met and downstream molecules was investigated based on public databases and also confirmed by the immunohistochemistry (IHC) staining of human tissues. Colony formation assay and sphere formation assay were conducted to verify the effect of HNK on the proliferation and stemness of PC cells. A subcutaneous transplanted tumor model of BALB\/c nude mice was established to explore the effect of HNK on modulating the tumor growth of PC in\u00a0vivo. c\u2010Met expression was significantly elevated in PC tissues versus normal pancreas tissues, and the high level of c\u2010Met was positively correlated with poor prognosis of PC patients. Overexpression of c\u2010Met significantly enhanced the proliferation and stemness of cancer cells, whereas HNK treatment reversed these effects. Critically, HNK suppressed tumor growth in\u00a0vivo by downregulating c\u2010Met. Our study reveals that HNK reduced the proliferation and stemness of PC cells via suppressing the c\u2010Met overexpression. These findings provide a potential therapeutic method for PC, offering new hope for improving patients' outcomes.<\/jats:p>","DOI":"10.1002\/ptr.70176","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:45:11Z","timestamp":1768038311000},"page":"873-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Honokiol Inhibits Stemness in Pancreatic Cancer via Downregulating c\u2010Met Expression"],"prefix":"10.1002","volume":"40","author":[{"given":"Yiqun","family":"Song","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"Pancreatic Disease Center of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The First 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