{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:59:05Z","timestamp":1785855545516,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ashwagandha (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Withania somnifera<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) is a well\u2010known adaptogen with established roles in stress modulation and physical performance enhancement traditionally. Low dose Ashwagandha (LDA\/Ashwa.30) is a bioactive\u2010optimized root\u2010only extract standardized to withanolides (&gt;\u200915% w\/w) and an ATP\u2010active fraction (&gt;\u200915% w\/w). This study investigated the efficacy and safety of LDA supplementation on cardiorespiratory fitness and exercise\u2010induced fatigue in healthy individuals. In this eight\u2010week, randomized, double\u2010blind, placebo\u2010controlled study, healthy adults received either LDA (30\u2009mg\/day) or placebo. VO\n                    <jats:sub>2<\/jats:sub>\n                    max was assessed as primary endpoint using an indirect method via the Modified Bruce Protocol Treadmill Test (MBPTT). Secondary endpoints included lactic acid, creatine phosphokinase (CPK), Rating of Perceived Exertion (RPE), fatigue scores (VAS), and safety biomarkers. LDA significantly improved VO\n                    <jats:sub>2<\/jats:sub>\n                    max and maximal heart rate compared to the placebo. Participants in the treatment group showed lower lactic acid levels at exercise, indicating prolonged aerobic metabolism. CPK levels were significantly reduced, suggesting mitigation of muscle energy stress. Borg RPE and fatigue scores improved in the LDA group. LDA was well tolerated, with no treatment\u2010related adverse events. Hematological, hepatic, renal, metabolic, and vital sign parameters remained within normal clinical ranges following intake of LDA. LDA supplementation for 8\u2009weeks significantly enhanced cardiorespiratory fitness, delayed fatigue onset, and was safe for use in healthy adults. These findings support its potential as a safe and effective low\u2010dose aid for endurance enhancement and overall exercise performance.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70178","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:39:26Z","timestamp":1773812366000},"page":"4978-4987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Low\u2010Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo\u2010Controlled, Double\u2010Blind, Clinical Trial"],"prefix":"10.1002","volume":"40","author":[{"given":"Himanshu","family":"Prajapati","sequence":"first","affiliation":[{"name":"Prajna Health Care  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Satia","sequence":"additional","affiliation":[{"name":"Ethicare Clinical Trial Services (OPC) Pvt. Ltd.  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhara","family":"Shah","sequence":"additional","affiliation":[{"name":"Ethicare Clinical Trial Services (OPC) Pvt. Ltd.  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Basera","sequence":"additional","affiliation":[{"name":"Ethicare Clinical Trial Services (OPC) Pvt. Ltd.  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvi","family":"Shah","sequence":"additional","affiliation":[{"name":"Ethicare Clinical Trial Services (OPC) Pvt. Ltd.  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hsr.2023.100092"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/960363"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.21760\/jaims.8.8.28"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14051011"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.43.4.207"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.11.011"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1699642"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114101"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428958"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2021.100434"},{"issue":"3","key":"e_1_2_12_12_1","first-page":"91","article-title":"Effect of Ashwagandha (\n                     Withania somnifera\n                  ) Root Powder Supplementation on the VO2 Max. And Hemoglobin in Hockey Players","volume":"2","author":"Malik A.","year":"2013","journal-title":"International Journal of Behavioral Social and Movement Sciences"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2020.1741484"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11050736"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06552-x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43024-x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0022-4707.16.06283-6"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488409789375311"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041119"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2014.0177"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7788.72485"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-9476.104444"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000000356"},{"key":"e_1_2_12_24_1","first-page":"2510","article-title":"Effect of \n                     Withania somnifera\n                   on Physical and Cardiovascular Performance Induced by Physical Stress in Healthy Human Volunteers","volume":"5","author":"Tripathi R. K.","year":"2016","journal-title":"International Journal of Basic & Clinical Pharmacology"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.202400188"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.70178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.70178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.70178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:42:58Z","timestamp":1785854578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.70178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ptr.70178"],"URL":"https:\/\/doi.org\/10.1002\/ptr.70178","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"2025-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}