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Due to their high prevalence rate, metabolic diseases have become a global public health challenge. The effect of polyphenols on gut microbiota\u2010derived metabolites is considered one of the main mechanisms through which they exert their benefits on metabolic diseases. However, comprehensive summarization of the interactions between polyphenols and metabolic diseases is still lacking, especially from the perspective of gut microbiota\u2010derived metabolites. In this review, we first discussed the effects of polyphenols on gut microbiota\u2010derived metabolites and relevant mechanisms. Polyphenols affect these metabolites by regulating gut microbiota composition, impacting enzymes, receptors, and transporters. 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