{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:56:03Z","timestamp":1783137363578,"version":"3.54.6"},"reference-count":96,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neurological disorders are leading causes of disability and death worldwide, yet many patients still face delayed diagnosis, limited disease\u2010modifying options and substantial treatment\u2010related adverse effects. Traditional Chinese medicine (TCM) provides holistic, multi\u2010target interventions through acupuncture, herbal formulas and adjunctive therapies, but its mechanisms remain insufficiently defined. Metabolomics, which enables system\u2010wide profiling of small\u2010molecule metabolites, offers an objective way to characterise disease\u2010related metabolic networks and quantify the global effects of TCM. We systematically searched PubMed, Web of Science and China National Knowledge Infrastructure for studies published between January 2005 and June 2025 that evaluated TCM\u2010related interventions for neurological disorders and reported metabolomic outcomes. Peer\u2010reviewed animal and clinical studies were included, whereas reviews, conference abstracts, methodological\u2010only papers and non\u2010neurological studies were excluded. Across Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), ischaemic stroke (IS), epilepsy and high\u2010altitude cerebral oedema (HACE), consistent alterations were identified in amino acid, lipid and energy\u2010related pathways, such as nicotinamide and lysophosphatidylcholine species in AD, branched\u2010chain amino acids in PD and phenylalanine and asymmetric dimethylarginine in MS. Metabolomics studies indicate that acupuncture and herbal formulas can jointly modulate neurotransmitter balance, cerebral energy metabolism, oxidative stress, neuroinflammation and blood\u2013brain barrier integrity. Emerging spatial metabolomics based on mass spectrometry imaging links individual TCM components, including ginsenosides and Astragalus membranaceus\u2010\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Carthamus tinctorius<\/jats:italic>\n                    <\/jats:styled-content>\n                    decoctions, to region\u2010specific metabolic reprogramming in the cortex, hippocampus and thalamus. However, most metabolite\u2010disease associations are correlative and are constrained by small sample sizes, heterogeneous designs and lack of technical standardisation. Metabolomics therefore provides a quantitative framework to dissect the multi\u2010target mechanisms of TCM in neurology and to connect molecular changes with functional outcomes. Standardised workflows, larger multicentre clinical studies and integration of spatial metabolomics, multi\u2010omics and artificial\u2010intelligence\u2010based analysis are required to translate these findings into TCM\u2010informed precision diagnosis and personalised treatment for neurological disorders.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70182","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T10:55:28Z","timestamp":1768042528000},"page":"829-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabolomics\u2010Driven Integration of Traditional Chinese Medicine for Neurological Disorders: From Precision Diagnosis to Therapeutic Innovation"],"prefix":"10.1002","volume":"40","author":[{"given":"Dongmei","family":"Mai","sequence":"first","affiliation":[{"name":"Guangdong Provincial Second Hospital of Traditional Chinese Medicine Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zurong","family":"Cao","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqing","family":"Tan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Second Hospital of Traditional Chinese Medicine Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine  Guangzhou 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