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The excessive recruitment of neutrophils accompanied by the formation of neutrophil extracellular traps (NETs) plays an important role in excessive inflammation caused by viral\u2010bacterial co\u2010infection, but effective pharmacological interventions remain lacking. Our study revealed that quercitrin (QTN), a flavonoid commonly found in traditional Chinese medicine and daily diets, significantly reduced mortality, recruitment of neutrophils, the production of inflammatory cytokines, and viral and bacterial loads in H1N1 influenza and methicillin\u2010resistant\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MRSA) coinfection\u2010induced pneumonia in mice. Mechanistically, QTN down\u2010regulates the interaction between Histone H3 and myeloperoxidase (MPO), thereby mitigating excessive inflammation induced by NETs. Our study demonstrates that inhibiting NETosis with QTN is one of the effective strategies for co\u2010infection treatment.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70190","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T21:58:43Z","timestamp":1768168723000},"page":"924-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quercitrin Inhibits\n                    <scp>NETosis<\/scp>\n                    via Histone\n                    <scp>H3<\/scp>\n                    to Alleviate the Severity of Viral Pneumonia With Drug\u2010Resistant Bacteria Co\u2010Infection in Mice"],"prefix":"10.1002","volume":"40","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Natural Medicine School of Pharmacy, Fudan University  Shanghai China"},{"name":"National Key Laboratory of Lead Druggability Research Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Natural Medicine School of Pharmacy, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilian","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Natural Medicine School of Pharmacy, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Natural Medicine School of Pharmacy, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linfeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Natural Medicine School of Pharmacy, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Lead Druggability Research Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunlong","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daofeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Natural Medicine School of Pharmacy, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652014000100009"},{"key":"e_1_2_11_3_1","first-page":"pe11","article-title":"Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death","volume":"379","author":"Benjamin E. 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