{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:31:52Z","timestamp":1793269912139,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hair loss and skin conditions have a detrimental influence on personality, health, and quality of life (QoL). Herbs from Ayurveda, such as ashwagandha having multimodal biological activities, are being researched as potential remedies for this issue. This prospective, randomized, double\u2010blind, placebo\u2010controlled comparative trial was carried out to evaluate the safety and efficacy of standardized Ashwagandha root extract on skin and hair related metrics in healthy adults.\u00a0Participants between 18 and 60\u2009years with hair loss or skin conditions were randomized to receive either an Ashwagandha capsule (300\u2009mg\/twice daily) or a Placebo treatment. The participants were assessed on Day 1 and 75 for change in efficacy indices, which included Transepidermal water loss (TEWL), TrichoScan hair parameters, and quality of life (QoL). The Ashwagandha group demonstrated greater improvement in TEWL and a substantial improvement in hair\u2010related parameters (density, growth, anagen, telogen, and anagen: telogen ratio) compared to Placebo (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) on day 75. When compared to the placebo, the Ashwagandha group demonstrated significant improvement in skin specific QoL, evidenced by a lower DLQI score (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Similarly, hair\u2010specific QoL was considerably improved, as revealed by a lower score on the Hair\u2010specific Skindex\u201029 compared to the Placebo (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The oral administration of Ashwagandha root extract\u00a0for 75\u2009days improved skin\u2010related and hair\u2010related parameters. No adverse drug events were encountered. Therefore, Ashwagandha root extract can hold promises for enhancing the skin and hair quality in healthy adults.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70199","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:25:58Z","timestamp":1773008758000},"page":"4946-4959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective, Randomized, Double\u2010Blind, Placebo\u2010Controlled Clinical Study of Efficacy and Safety of Ashwagandha Root Extract Capsule on Skin and Hair Health in Healthy Adults"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-2194","authenticated-orcid":false,"given":"Aditya","family":"Jillella","sequence":"first","affiliation":[{"name":"Skintis Clinic Medical and Cosmetic Dermatology and Gynaecology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Keerthi","sequence":"additional","affiliation":[{"name":"Skintis Clinic Medical and Cosmetic Dermatology and Gynaecology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Venkateswar Reddy","sequence":"additional","affiliation":[{"name":"Skintis Clinic Medical and Cosmetic Dermatology and Gynaecology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526520666200622142710"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568010054022033"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.09.001"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X61820"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114744"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1201\/b10787"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1991.tb03277.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092407"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253\u20107176.106022"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100625.2002.00112.x"},{"issue":"2","key":"e_1_2_13_12_1","first-page":"189","article-title":"Female Pattern Hair Loss: Current Treatment Concepts","volume":"2","author":"Dinh Q. 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