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Leonurine can protect BMSCs from oxidative stress, while the role and molecular mechanism of leonurine on OP is unclear. The primary BMSCs from OP rats (OP\u2010BMSCs) were extracted and cultured in\u00a0vitro. Next, we observed the effects of different concentrations of leonurine on cell viability, ROS level and osteoblast differentiation. Additionally, the change levels of ferroptosis and bone microstructure were examined. RNA sequencing was used to analyze the signaling pathway and the MAPK signaling pathway was explored in\u00a0vitro. Finally, the functions of osteoclasts were estimated. Leonurine downregulated ROS levels, upregulated the expression of antioxidative genes and osteogenic\u2010related markers in OP\u2010BMSCs via inhibiting ferroptosis depending on upregulating the phosphorylation of JNK. Additionally, the supernatant of OP\u2010BMSCs promoted the M1 polarization and inhibited M2 polarization, which will be suppressed after co\u2010culture of leonurine and OP\u2010BMSCs in\u00a0vitro\n                    <jats:italic>.<\/jats:italic>\n                    Leonurine could promote the osteogenic function of BMSCs via the inhibition of ferroptosis depending on the JNK signaling pathway and inhibit osteoclastic differentiation by the promotion of M2 polarization, which represents a potential therapeutic approach for OP.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70200","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:59:57Z","timestamp":1771318797000},"page":"2456-2472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Leonurine Maintains\n                    <scp>BMSCs<\/scp>\n                    Stemness From Osteoporotic Rats Through Inhibiting Ferroptosis Depending on the\n                    <scp>JNK<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"40","author":[{"given":"Dongmei","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Shanghai Stomatological Hospital, Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Fudan University  Shanghai China"},{"name":"Medical College, Anhui University of Science and Technology  Huainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Fudan University  Shanghai China"},{"name":"Department of Endodontics Shanghai Stomatological Hospital, Fudan University  Shanghai 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