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Although current pharmacological treatments offer only transient symptomatic relief and do not effectively arrest the underlying disease process, oxidative stress has been recognized as a pivotal contributor to PD pathogenesis and thus represents a key therapeutic target. Over the past decade, a growing body of evidence has indicated that selected natural compounds can ameliorate PD\u2010related manifestations by modulating oxidative stress. Their putative neuroprotective actions and associated molecular mechanisms have been partially characterized in preclinical investigations, including in\u00a0vitro cell models and in\u00a0vivo animal studies. Nevertheless, the majority of current studies on these natural components are still confined to the preclinical setting, and their clinical efficacy has yet to be substantiated by rigorous, high\u2010quality evidence. Robust randomized controlled trials with multicenter participation, adequate sample sizes, and extended follow\u2010up are urgently required to facilitate their safe and effective translation into clinical practice. This review highlights natural compounds, including polyphenols, flavonoids, glycosides, terpenoids, and alkaloids, and synthesizes current knowledge regarding their neuroprotective potential and mechanisms, with the goal of informing future PD\u2010focused research on natural products and guiding the development of novel therapeutic strategies.<\/jats:p>","DOI":"10.1002\/ptr.70214","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:43:20Z","timestamp":1770018200000},"page":"1810-1836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Progress of Natural Components Improving Parkinson's Disease by Regulating the Oxidative Stress"],"prefix":"10.1002","volume":"40","author":[{"given":"Wei","family":"Jiang","sequence":"first","affiliation":[{"name":"Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional 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