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Its pathogenesis involves multiple factors such as inflammatory responses, cartilage metabolic disorders, and abnormal mechanical stress. Current pharmacological interventions primarily offer symptomatic relief. Non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs), whereas commonly used, do not arrest disease progression and are associated with potential cardiovascular and renal adverse effects when used long\u2010term. Historically, natural herbs have been employed in the management of OA for millennia and are increasingly recognized as promising candidates for the development of disease\u2010modifying therapies. This review provides a systematic overview of the research advancements concerning 14 natural herbs in the context of OA treatment. It highlights the capacity of these herbal medicines to concurrently influence pathways associated with inflammation and cartilage metabolism. The bioactive constituents of these herbs are classified based on structural characteristics into categories such as polysaccharides, flavonoids, and terpenoids. Importantly, the review identifies mechanistic similarities among compounds within the same category. 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