{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:31:04Z","timestamp":1792521064117,"version":"4.5.0"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019752","name":"Neyshabur University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Curcuminoids are dietary polyphenols that can improve health indices through various mechanisms, such as anti\u2010inflammatory, antioxidant, and other clinical properties. Due to the lack of evidence on the efficacy of curcuminoids in critically ill patients, this meta\u2010analysis was conducted. The aim of this study was to assess and quantify the influence of curcumin supplementation on markers of inflammation, liver function, and clinical outcomes in critically ill patients. In this study, relevant randomized clinical trials were identified via electronic database searches, including MEDLINE, Scopus, and Web of Science, up until January 2025. The Cochrane risk\u2010of\u2010bias tool was utilized to assess the quality of the studies. Standardized mean differences (SMDs) and risk ratio (RR) in changes between intervention and placebo groups were calculated. Both random\u2010effects and fixed\u2010effects models were applied, and pre\u2010specified stratified analyses were performed to explore potential sources of heterogeneity. Out of a total of 691 studies screened, seven trials met the inclusion criteria, encompassing data from 571 participants. The pooled analysis demonstrated that curcumin supplementation significantly lowered alanine transaminase (ALT) levels (SMD: \u22120.4, 95% CI: \u22120.8 to \u22120.001,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), total bilirubin levels (SMD: \u22120.4, 95% CI: \u22120.9 to \u22120.07,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01), Sequential Organ Failure Assessment (SOFA) scores (SMD: \u22120.8, 95% CI: \u22121.2 to \u22120.4,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), the duration of intensive care unit (ICU) stays (SMD: \u22120.3\u2009days, 95% CI: \u22120.6 to \u22120.1,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01), compared to placebo. Furthermore, curcumin supplementation was associated with significant increases in albumin (SMD: 0.3, 95% CI: 0.001 to 0.6,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004) and alkaline phosphatase levels (SMD: 0.4, 95% CI: 0.02 to 0.8,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). This meta\u2010analysis demonstrates that curcumin supplementation improves liver function, albumin levels, SOFA scores, and ICU stay duration in critically ill patients, suggesting its potential role in mitigating organ dysfunction in this population.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70238","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:06:17Z","timestamp":1770447977000},"page":"2081-2097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin Supplementation in Critically Ill Patients: A\n                    <scp>GRADE<\/scp>\n                    \u2010Assessed Systematic Review and Meta\u2010Analysis of Randomized Controlled Trial"],"prefix":"10.1002","volume":"40","author":[{"given":"Seyyed Mostafa","family":"Arabi","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Biochemistry, Faculty of Medicine Neyshabur University of Medical Sciences  Neyshabur Razavi Khorasan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mollahasni","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Biochemistry, Faculty of Medicine Neyshabur University of Medical Sciences  Neyshabur Razavi Khorasan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Azarian","sequence":"additional","affiliation":[{"name":"Dezful Branch Islamic Azad University  Dezful Khuzestan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahla","family":"Chambari","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Faculty of Applied Sciences UCSI University  Cheras Kuala Lumpur Malaysia"},{"name":"Faculty of Medicine Navoi State University  Navoi Razavi Khorasan Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila Sadat","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Biochemistry, Faculty of Medicine Neyshabur University of Medical Sciences  Neyshabur Razavi Khorasan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University  Chennai Tamil Nadu India"},{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Razavi Khorasan Iran"},{"name":"Applied Biomedical Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences  Mashhad Razavi Khorasan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867331666230821095329"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43088\u2010024\u201000590\u2010x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)60446\u20101"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12131"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1051\/bmdcn\/2019090423"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2022.10694"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121912"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2014.12.025"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673309489240816063313"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184.ch9"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604.ch10"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2421"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341x.2000.00455.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10070855"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27362"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.039818"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.02.008"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666210525124707"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9130979"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7284"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26620"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44466\u2010025\u201000014\u20100"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.22038\/ajp.2022.20201"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u20105\u201013"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01635-4"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2020.101122"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo03746c"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1037861"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2016.10.001"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155635"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.146.9.3032"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.07130622"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201073234\u20109_2"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010024\u201004639\u20103"},{"issue":"4","key":"e_1_2_12_38_1","first-page":"352","article-title":"The Effect of Curcumin on TNF\u2010\u03b1, IL\u20106 and CRP Expression in a Model of Polycystic Ovary Syndrome as an Inflammation State","volume":"18","author":"Mohammadi S.","year":"2017","journal-title":"J Reprod Infertil"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2017.1358139"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291\u2010016\u20100202\u20107"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14093"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.06.032"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27615"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5211"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101389986"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/19390211.2014.952865"},{"key":"e_1_2_12_48_1","first-page":"1","volume-title":"Advances in Experimental Medicine and Biology","author":"Panahi Y.","year":"2021"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2012.012040"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200805\u2010722OC"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2020.102322"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.07.1071"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1062"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5045"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.140\u2010c1"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnv024"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4952"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.12.016"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.EHX.0000455822.82783.4b"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.01.032"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104353"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.04.043"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000002342"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.01.015"},{"issue":"1","key":"e_1_2_12_65_1","first-page":"5","article-title":"The Relationship of Parathyroid Hormone and Calcium Levels With the Severity of Illness and Prognosis in Sepsis Patients","volume":"13","author":"Xiping W.","year":"2012","journal-title":"J Clin Emerg"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110525"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7179"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040928"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.70238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.70238","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.70238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:22:18Z","timestamp":1775622138000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.70238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/ptr.70238"],"URL":"https:\/\/doi.org\/10.1002\/ptr.70238","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"2025-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}