{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:08:12Z","timestamp":1788872892075,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["9423004"],"award-info":[{"award-number":["9423004"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Interleukin 4 (IL\u20104)\u2010mediated apoptosis is involved in the pathogenesis of atherosclerosis both through efferocytosis overload and direct cellular signalling pathways. This study explored the mechanism of dehydrocorydaline (DHC), a potential therapeutic agent for atherosclerosis derived from\n                    <jats:italic>Corydalis yanhusuo<\/jats:italic>\n                    . An experimental model of atherosclerosis was established in high\u2010fat diet\u2010induced ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, with DHC intervention administered during the final 4\u2009weeks of the protocol. We used an integrated approach combining molecular docking, molecular dynamics and target validation through microscale thermophoresis to elucidate the molecular mechanisms underlying the antiatherosclerotic effects of DHC. The experimental results demonstrated that DHC exerted significant antiatherosclerotic effects in atherosclerotic mice, primarily through attenuation of pathological apoptosis within plaques and suppression of inflammatory responses. Subsequent molecular analysis revealed that DHC binds strongly to signal transducer and activator of transcription 3 (STAT3). DHC treatment mitigated dysregulated efferocytosis secondary to apoptotic overload and inflammatory responses in macrophages both in\u00a0vivo and in\u00a0vitro, cultured by specifically inhibiting the IL\u20104\u2010activated STAT3\/Bcl\u20102 axis. This study demonstrates that DHC exerts anti\u2010atherosclerotic effects by reprogramming macrophage fate to restore efferocytosis. Mechanistically, DHC uncouples STAT3 phosphorylation from its transcriptional output, reducing overall p\u2010STAT3 while specifically enhancing its binding to the\n                    <jats:italic>Bcl\u20102<\/jats:italic>\n                    promoter to upregulate this pro\u2010survival gene. This dual action modulates global STAT3 activity while potentiating a local survival signal and rebalances the apoptosis\u2010efferocytosis axis. Our results elucidate a novel pharmacological strategy of context\u2010dependent STAT3 pathway modulation and highlight DHC as a promising therapeutic candidate for stabilising atherosclerotic plaques.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70273","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:38:26Z","timestamp":1771313906000},"page":"2473-2490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dehydrocorydaline Promotes\n                    <scp>STAT3<\/scp>\n                    \/Bcl\u20102 Axis\u2010Mediated Macrophage Efferocytosis to Attenuate Apoptosis in Atherosclerotic Plaques"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3459-9539","authenticated-orcid":false,"given":"Li","family":"Hongzheng","sequence":"first","affiliation":[{"name":"Guang'anmen Hospital, China Academy of Chinese Medical Sciences  Beijing People's Republic of China"},{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Zucheng","sequence":"additional","affiliation":[{"name":"Guang'anmen Hospital, China Academy of Chinese Medical Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Aimei","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital, Beijing University of Chinese Medicine  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wenwen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaanxi Provincial Hospital of Chinese Medicine  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Mengfan","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wenrui","sequence":"additional","affiliation":[{"name":"Guang'anmen Hospital, China Academy of Chinese Medical Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Wenjing","sequence":"additional","affiliation":[{"name":"Guang'anmen Hospital, China Academy of Chinese Medical Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Xin","sequence":"additional","affiliation":[{"name":"Guang'anmen Hospital, China Academy of Chinese Medical Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zikai","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Chinese Medicine 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