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Pogostone (PO), a major component of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pogostemon cablin<\/jats:italic>\n                    <\/jats:styled-content>\n                    , has anti\u2010inflammatory, immunosuppressive, and antioxidant properties. In this study, we characterized the therapeutic potential of PO in remyelination and elucidated the underlying mechanisms. In cuprizon (CPZ)\u2010induced demyelinating mice, rotarod test, RNA sequence, molecular docking, immunofluorescence, and western blotting were used to analyze the targets and signaling pathways involved in PO treatment. Meanwhile, the changes of mitophagy and NLRP3 inflammasome were detected after further treatment with RXR\u03b3 antagonist UVI3003. In lipopolysaccharide (LPS)\u2010induced BV2 microglia, after interference with RXR\u03b3 or blockade of mitophagy by 3\u2010methyladenine (3\u2010MA), the effects of PO on mtROS, mitochondrial membrane potential (MMP), NLRP3 inflammasome and mitophagy were measured by flow cytometry, immunofluorescence and western blotting. PO treatment effectively promoted remyelination in the CPZ model, and this effect was achieved by activating RXR\u03b3. Meanwhile, PO suppressed microglial NLRP3 inflammasome activation through enhancement of PINK1\/Parkin\u2010mediated mitophagy, but this change was reversed by the RXR\u03b3 antagonist UVI3003. In LPS\u2010induced BV2 microglia, interference with RXR\u03b3 reversed the inhibitory effect of PO on mtROS production, MMP decline, and NLRP3 activation. In addition, blockade of mitophagy by 3\u2010MA reversed the inhibitory effects of PO on mtROS production and NLRP3 inflammasome activity. The present study demonstrated that PO suppresses microglial NLRP3 inflammasome activation\u2010promoted remyelination via RXR\u03b3 regulation of mitophagy, which suggests PO as a promising drug candidate for the treatment of MS.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70277","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:59:47Z","timestamp":1773071987000},"page":"2844-2861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pogostone Suppresses Microglial\n                    <scp>NLRP3<\/scp>\n                    Inflammasome Activation\u2010Promoted Remyelination Through\n                    <scp>RXR\u03b3<\/scp>\n                    Regulation of Mitophagy"],"prefix":"10.1002","volume":"40","author":[{"given":"Menghan","family":"Qian","sequence":"first","affiliation":[{"name":"School of Medicine, Yunnan University  Kunming 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