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However, the specific role and molecular mechanism of CA in gastric cancer (GC) remain unclear. This study aimed to elucidate its effects on GC cell proliferation, migration, epithelial\u2010mesenchymal transition (EMT), and drug resistance, and to explore the potential involvement of follistatin\u2010like 3 (FSTL3) in these processes. The study employed both in\u00a0vitro and in\u00a0vivo approaches. In\u00a0vitro, GC cells were treated with CA to assess its impact on cell proliferation, migration, and EMT. The expression and role of FSTL3 were analyzed. In\u00a0vivo, the GC xenograft model and intrasplenic injection liver metastasis model were used to confirm the antitumor effects and the ability to resist metastasis of CA. CA treatment significantly downregulated the expression of FSTL3 in GC cells and altered cytoskeleton expression and distribution. Functionally, CA effectively inhibited GC cell proliferation and migration. These antitumor effects were crucially mediated through FSTL3. The in\u00a0vivo experiments consistently demonstrated that CA suppressed GC tumor growth, invasion, and metastasis by modulating the expression of EMT\u2010related proteins and TGF\u2010\u03b2\/SMAD signaling via FSTL3. This study demonstrates that the antitumor effects of CA on GC are primarily mediated through FSTL3 downregulation. These findings implicate FSTL3 as a promising therapeutic target for treating GC and overcoming drug resistance.<\/jats:p>","DOI":"10.1002\/ptr.70292","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:35:59Z","timestamp":1774312559000},"page":"3212-3228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cinnamaldehyde Regulates the\n                    <scp>EMT<\/scp>\n                    Process and Drug Resistance of Gastric Cancer Through\n                    <scp>FSTL3<\/scp>\n                    \u2010Mediated Cytoskeletal Remodeling"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5548-790X","authenticated-orcid":false,"given":"Shuhong","family":"Zeng","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine  Nanjing China"},{"name":"No.1 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