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Prolonged and severe DM often leads to debilitating complications, including diabetic neuropathy (DN), retinopathy (DR), nephropathy (DNP), and cardiomyopathy. Several studies have demonstrated that overwhelming oxidative stress, chronic inflammatory responses, and mitochondrial dysfunction are major contributors to these underlying diabetes\u2010related complications. Current therapeutic strategies, including insulin intake and use of oral hypoglycemics, often fail to prevent or reduce the progression of microvascular and neurodegenerative complications, thus warranting an alternative, multi\u2010targeted intervention.\n                    <jats:italic>Bacopa monniera<\/jats:italic>\n                    (BM), a traditional medicinal herb rich in bacosides, saponins, and flavonoids, has demonstrated potent antioxidant, anti\u2010inflammatory, and neuroprotective effects in preclinical models. However, comprehensive evaluations of BM efficacy across multiple diabetes\u2010related complications and mechanistic pathways remain limited. This review consolidates current evidence on the role of BM in mitigating diabetes\u2010related complications, emphasizing its ability to alleviate oxidative stress, suppress pro\u2010inflammatory cytokine response, preserve mitochondrial integrity, and protect neuronal and vascular structural integrity. By bridging existing gaps in the literature, this work highlights BM as a promising phytotherapeutic drug in diabetes management, especially for combating the metabolic and neurovascular complications in severe DM.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70293","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:29:20Z","timestamp":1773156560000},"page":"4960-4977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Bacopa monniera<\/i>\n                    : A Promising Phytotherapeutic Approach in Management of Diabetes\u2010Related Complications"],"prefix":"10.1002","volume":"40","author":[{"given":"H. S.","family":"Bhumika","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Natural Sciences, Adichunchanagiri School of Natural Sciences Adichunchanagiri University  B.G. Nagara Karnataka India"},{"name":"Center for Research and Innovation, Faculty of Natural Sciences Adichunchanagiri University  B.G. Nagara Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4988-5180","authenticated-orcid":false,"given":"M. D.","family":"Pandareesh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Natural Sciences, Adichunchanagiri School of Natural Sciences Adichunchanagiri University  B.G. Nagara Karnataka India"},{"name":"Center for Research and Innovation, Faculty of Natural Sciences Adichunchanagiri University  B.G. Nagara Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Narasaraju","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation, Faculty of Natural Sciences Adichunchanagiri University  B.G. 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