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MAFLD is a metabolic stress disorder characterized by excessive fat deposition in hepatocytes in addition to alcohol and other liver\u2010damaging factors, and it has become the most common chronic disease in the world, and the effective treatment of MAFLD has become an urgent issue in contemporary medicine. Effective treatment of MAFLD has become a key issue in contemporary medicine. The pathogenesis of MAFLD involves disorders of glucose and lipid metabolism, oxidative stress, endoplasmic reticulum stress, the intestinal\u2010hepatic axis, and intestinal flora. Traditional Chinese medicine (TCM) compounds have a wide range of pharmacological activities, and a large number of clinical studies and TCM studies have confirmed that TCM flavonoids can affect the development of MAFLD at multiple interrelated levels, thus showing great potential as anti\u2010MAFLD drugs. In this paper, we reviewed the research progress and mechanism of action of flavonoids in traditional Chinese medicine to improve MAFLD. Taking total flavonoid extracts of traditional Chinese medicine and flavonoid monomer compounds of traditional Chinese medicine as the main categories, we sorted out the preventive and treatment effects and mechanisms of 18 total flavonoids of traditional Chinese medicine and 28 flavonoid monomer compounds of traditional Chinese medicine against MAFLD and put forward the direction of structural modification of MAFLD to promote the research and development of drugs for the treatment of MAFLD, providing a theoretical basis for the research and development of drugs. It provides a theoretical basis for the research and development of drugs for MAFLD.<\/jats:p>","DOI":"10.1002\/ptr.70298","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:48:29Z","timestamp":1775465309000},"page":"3478-3503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanism of Action and Research Progress of Flavonoids From Traditional Chinese Medicine to Improve Metabolic Liver Disease"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9604-6035","authenticated-orcid":false,"given":"Xuehui","family":"Tao","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangtong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoming","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf3001108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010017\u20109798\u2010x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010020\u20100269\u20109"},{"issue":"7","key":"e_1_2_9_5_1","first-page":"1091","article-title":"Effect of Ginkgo Flavonoids on the Expression of Toll\u2010Like Receptor\u20104 and Nuclear Factor\u2010\u03baB in the Liver of Mice With Nonalcoholic Fatty Liver Disease","volume":"31","author":"Bai J.","year":"2015","journal-title":"Journal of Practical Medicine"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"342","article-title":"Endoplasmic Reticulum Stress and Pathological Angiogenesis\u2010Related 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