{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:34:16Z","timestamp":1789468456020,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Most Germans consider herbal medicinal products (HMPs) to be an important supplement to conventional medicine. Despite existing clinical evidence for safety and efficacy, they are still not sufficiently integrated into drug therapy of gynaecological complaints in everyday practice. By analysing patient\u2010reported outcomes (PROs), this gap in medical care can be closed. Real\u2010world data was extracted from the pharmaco\u2010epidemiological database PhytoVIS. We analysed a sample (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091658) containing PROs from women who utilised HMPs to treat their gynaecological complaints applying descriptive and non\u2010parametric bivariate statistical tests. Perceived effectiveness and tolerability of HMPs was rated as very good. For the treatment of menstrual complaints,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vitex agnus\u2010castus<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. was primarily used, and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Actaea racemosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. for menopausal complaints. Various herbal drugs were applied for uncomplicated urinary tract infections (uUTIs), but mainly\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Arctostaphylos uva\u2010ursi<\/jats:italic>\n                    <\/jats:styled-content>\n                    (L.) Spreng. Regarding the pharmaceutical form, herbal teas were preferred for the treatment of uUTIs or by very young or elderly women. All other pharmaceutical forms were favoured for menstrual and menopausal complaints or middle\u2010aged women. The pharmaceutical form did not impact the perceived therapeutic effectiveness. Our results provide valuable insights into patient preferences and show options for their integration into existing treatment strategies. By identifying the most popular and efficacious plants for certain gynaecological ailments, we support healthcare providers to better address the growing demand for complementary treatment options. This knowledge helps in tailoring healthcare to meet patient needs and to ensure the safety and efficacy of HMPs.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70321","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:36:52Z","timestamp":1775464612000},"page":"3580-3594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Trends and Patterns for the Use of Herbal Medicinal Products for Gynaecological Ailments"],"prefix":"10.1002","volume":"40","author":[{"given":"Alexandra","family":"Drebka","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Biology, Goethe\u2010University  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika J.","family":"Scholl","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Biology, Goethe\u2010University  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ochs","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Biology, Goethe\u2010University  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Kelber","sequence":"additional","affiliation":[{"name":"R&amp;D, Phytomedicines Supply and Development Center, Bayer Consumer Health Steigerwald Arzneimittelwerk GmbH  Darmstadt Germany"},{"name":"Kooperation Phytopharmaka GbR  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-810X","authenticated-orcid":false,"given":"Ralph","family":"M\u00f6sges","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology, University of Cologne  Cologne Germany"},{"name":"ClinCompetence Cologne GmbH  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-7354","authenticated-orcid":false,"given":"Beatrice E.","family":"Bachmeier","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Biology, Goethe\u2010University  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2007.04.009"},{"key":"e_1_2_13_3_1","first-page":"1","volume-title":"R\u00fcckgang Der Pillen\u2010Verordnungen Um Zehn Prozentpunkte Innerhalb Von Drei Jahren","author":"Behrens K.","year":"2024"},{"key":"e_1_2_13_4_1","unstructured":"BGA\/BfArM KEM.1985.\u201cPotentillae Anserinae Herba (G\u00e4nsefingerkraut) \u201d."},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2007.04.008"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-017-0791-0"},{"key":"e_1_2_13_7_1","volume-title":"Press Release Forsa\u2010Survey Herbal Medicines","author":"Compafarm","year":"2021"},{"key":"e_1_2_13_8_1","unstructured":"DGGG L.2020.\u201cPeri\u2010 und Postmenopause \u2013 Diagnoastik und Interventionen \u201d."},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.02.012"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15013-016-0998-6"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.01.006"},{"key":"e_1_2_13_12_1","unstructured":"HMPC.2016.\u201cAssesment Report on Salvia Officinals L. Folium and Salvia Officinals L. Aetheroleum London UK: European Medicines Agency (EMA) \u201d."},{"key":"e_1_2_13_13_1","unstructured":"HMPC.2018a.\u201cGuideline on Quality of Herbal Medicinal Products\/Traditional Herbal Medicinal Products \u2010 DRAFT Revision 3.\u201dEuropean Medicines Agency (EMA).http:\/\/www.ema.europe.eu."},{"key":"e_1_2_13_14_1","volume-title":"Assessment Report on Vitex agnus\u2010castus L., Fructus","author":"HMPC","year":"2018"},{"key":"e_1_2_13_15_1","volume-title":"Assessment Report on Cimicifuga racemosa (L.) Nutt., Rhizoma","author":"HMPC","year":"2018"},{"key":"e_1_2_13_16_1","unstructured":"(Hrsg.) DGfUeV.2024.S3 Leitlinie: Epidemiologie Diagnostik Therapie Pr\u00e4vention und Management Unkomplizierter Bakterieller Ambulant Erworbener Harnwegsinfektionen bei Erwachsenen \u2013 Aktualisierung 2024. 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