{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:51:36Z","timestamp":1782312696151,"version":"3.54.5"},"reference-count":189,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The transcription factor p53, often called the \u201cguardian of the genome,\u201d is critical for preserving genomic integrity. Mutations in the\n                    <jats:italic>TP53<\/jats:italic>\n                    gene are found in approximately half of all human malignancies, including breast, colon, lung, liver, prostate, bladder, and skin cancers. p53 is activated by a wide range of cellular stress signals and orchestrates specific cellular responses based on the context and nature of the stress. As a tumor suppressor, p53 controls cancer initiation and progression by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. Beyond its classical role in genome surveillance, p53 is now recognized as a dynamic signaling hub whose functions can be therapeutically modulated in cancer. Natural products derived from medicinal plants represent a rich source for discovering and developing novel therapeutic and preventive agents against cancer. Several natural compounds have been reported to target mutant p53 in cancer cells, offering a potentially effective strategy for modulating the p53 signaling pathway. This review highlights recent advances in identifying and developing anticancer natural products that modulate the expression or activity of the p53 tumor suppressor gene for cancer treatment and prevention.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70323","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:46:08Z","timestamp":1776329168000},"page":"3840-3865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural Modulators of the\n                    <scp>TP53<\/scp>\n                    Pathway: Potential Herbal and Plant\u2010Derived Agents for Cancer Therapy"],"prefix":"10.1002","volume":"40","author":[{"given":"Sudeshna","family":"Nandi","sequence":"first","affiliation":[{"name":"Department of Botany Vedanta College  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghya","family":"Naskar","sequence":"additional","affiliation":[{"name":"Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany University of Calcutta  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somanjana","family":"Khatua","sequence":"additional","affiliation":[{"name":"Department of Botany, Faculty of Science University of Allahabad  Prayagraj Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnendu","family":"Acharya","sequence":"additional","affiliation":[{"name":"Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany University of Calcutta  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"B\u00fcsselberg","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine\u2010Qatar, Education City, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Herrera\u2010Bravo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Facultad de Ciencias Universidad Santo Tomas  Temuco Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-5800","authenticated-orcid":false,"given":"Alejandra","family":"Arancibia\u2010Diaz","sequence":"additional","affiliation":[{"name":"Escuela de Ingenier\u00eda Bioqu\u00edmica Pontificia Universidad Cat\u00f3lica de Valpara\u00edso  Valpara\u00edso Chile"},{"name":"IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-0528","authenticated-orcid":false,"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[{"name":"Aromatic Plant Research Center  Lehi Utah USA"},{"name":"Department of Chemistry University of Alabama in Huntsville  Huntsville Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Sanda","family":"Rotariu","sequence":"additional","affiliation":[{"name":"University of Life Sciences \u201cKing Mihai I\u201d From Timisoara  Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Aneta","family":"Dragunescu","sequence":"additional","affiliation":[{"name":"University of Life Sciences \u201cKing Mihai I\u201d From Timisoara  Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-5000","authenticated-orcid":false,"given":"Monica","family":"Butnariu","sequence":"additional","affiliation":[{"name":"University of Life Sciences \u201cKing Mihai I\u201d From Timisoara  Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi\u2010Rad","sequence":"additional","affiliation":[{"name":"Universidad Esp\u00edritu Santo  Samborond\u00f3n Ecuador"},{"name":"Centro de Estudios Tecnol\u00f3gicos y Universitarios del Golfo  Veracruz Mexico"},{"name":"Department of Medicine, College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5897\/JPP2013.0270"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.08.098"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5794350"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1174363"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5778411"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"139","article-title":"Flavopiridol Induces Apoptosis in Glioma Cell Lines Independent of Retinoblastoma and p53 Tumor Suppressor Pathway Alterations by a Caspase\u2010Independent Pathway","volume":"2","author":"Alonso M.","year":"2003","journal-title":"Molecular Cancer Therapeutics"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26189135"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14235733"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246257"},{"key":"e_1_2_12_11_1","volume-title":"Aprea Therapeutics Announces Results of Primary Endpoint From Phase 3 Trial of Eprenetapopt in TP53 Mutant Myelodysplastic Syndromes (MDS)","author":"Aprea Therapeutics","year":"2020"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121361"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-023-01253-7"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz268.105"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00414-2"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00848-3"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008879200"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3711"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4591-3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1455"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920107783018444"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1339905"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.035"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61389"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158268"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026104"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0196-9"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028308"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-025-00751-5"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02342"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.030254"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0204"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2016.60"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0593-42"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.001"},{"key":"e_1_2_12_36_1","first-page":"211","volume-title":"Recent Advances in p53","author":"D'Orazi G.","year":"2021"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1648395"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.07.005"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1093"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja002940p"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.172"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-00988-z"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2175com"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw523"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.02.019"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.871667"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.12.017"},{"key":"e_1_2_12_48_1","first-page":"883","volume-title":"In","author":"Freemantle S. J.","year":"2002"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv066"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038060"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.15698\/cst2020.07.224"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0661"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4283"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0110-x"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb06199.x"},{"issue":"1","key":"e_1_2_12_56_1","first-page":"3","article-title":"The Role of Tumor Protein 53 Mutations in Common Human Cancers and Targeting the Murine Double Minute 2\u2010p53 Interaction for Cancer Therapy. Iranian","volume":"37","author":"Hamzehloie T.","year":"2012","journal-title":"Journal of Medical Sciences"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90499-G"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13475"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010013"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.098863"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01169-0"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-0425"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20211143"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204981"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(06)97001-8"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.77.060806.091238"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000919"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-024-01391-6"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2012.6.2.188"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12634"},{"issue":"1","key":"e_1_2_12_71_1","first-page":"27","article-title":"Herbal Versus Synthetic Drugs; Beliefs and Facts","volume":"4","author":"Karimi A.","year":"2015","journal-title":"Journal of Nephropharmacology"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012414-040349"},{"issue":"8","key":"e_1_2_12_73_1","first-page":"1049","article-title":"Genetic Alterations in the Region of the p53 Gene on Human Chromosome 17 in Colorectal Cancer","volume":"34","author":"Kashkin K.","year":"1998","journal-title":"Genetika"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.028"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911408893"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12020303"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4935"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.012"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4007"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.876213"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/358015a0"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/278261a0"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.006"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.02.015"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013078107"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.5942"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cancerbio-030518-055455"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-2709"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3066"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.10.001"},{"issue":"3","key":"e_1_2_12_91_1","first-page":"400","article-title":"Ginsenoside Metabolite Compound K Enhances the Efficacy of Cisplatin in Lung Cancer Cells","volume":"7","author":"Li Y.","year":"2015","journal-title":"Journal of Thoracic Disease"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00104"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.10.1235"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01856-7"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03167"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.3.11.1189"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.06.004"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.9.4952"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-021-2093-2"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.23.16531"},{"key":"e_1_2_12_101_1","first-page":"878","article-title":"Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms","volume":"259","author":"Malkin D.","year":"1993","journal-title":"Erratum in Science"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.10.054"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02396-8"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.10.036"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.41"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.737951"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.14.5435"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.16"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00181"},{"issue":"6","key":"e_1_2_12_110_1","first-page":"1799","article-title":"Tumor Suppressor p53 Is a Regulator of Bcl\u20102 and Bax Gene Expression In\u00a0Vitro and In\u00a0Vivo","volume":"9","author":"Miyashita T.","year":"1994","journal-title":"Oncogene"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0158"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69722-4"},{"issue":"12","key":"e_1_2_12_113_1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/mc.20570","article-title":"Involvement of p53 in Oroxylin A\u2010Induced Apoptosis in Cancer Cells","volume":"48","author":"Mu R.","year":"2009","journal-title":"Molecular Carcinogenesis: Published in Cooperation With the University of Texas MD Anderson Cancer Center"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmcr.2024.100137"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2641"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401914"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238367"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14021"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2858"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1818"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34978"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.004"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001008"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145578"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04505-w"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-0219"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100573"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710539200"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.8.2391.2391"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2018.07.002"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00917"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.30.20160018"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8873"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3098"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5851"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026047"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1117"},{"key":"e_1_2_12_138_1","first-page":"1397","article-title":"Modulating the p53\u2010MDM2 Pathway: The Therapeutic Potential of Natural Compounds in Cancer Treatment","volume":"23","author":"Ramli I.","year":"2024","journal-title":"EXCLI Journal"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000548"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2067"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0005-8"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.04.011"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4675"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.249060"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02341"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.70164"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.073723"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10123154"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01435"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107s15"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9110679"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401865"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.288"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28186665"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005001200007"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28248038"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.6.1660"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1991-x"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.174"},{"key":"e_1_2_12_160_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood-2020-139022","article-title":"Phase 1 and Dose Expansion Study of APR\u2010246 in Combination With Ibrutinib or Venetoclax\u2010Based Therapy in Subjects With TP53\u2010Mutant Relapsed and\/or Refractory Non\u2010Hodgkin Lymphomas (NHL) Including Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)","volume":"136","author":"Thompson M. C.","year":"2020","journal-title":"Blood"},{"issue":"1","key":"e_1_2_12_161_1","first-page":"126","article-title":"Plumbagin Induces Apoptosis via the p53 Pathway and Generation of Reactive Oxygen Species in Human Osteosarcoma Cells","volume":"5","author":"Tian L.","year":"2012","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-008-0832-5"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.740578"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.09.052"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2022.02.010"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.08.016"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3430"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201510"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0270-7"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01347-1"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2020034510"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.11.016"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20742"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604227"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2399"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58366-z"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.10.043"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210294"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6177553"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2023068"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-017-0818-5"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110786"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(02)00322-6"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjaa040"},{"key":"e_1_2_12_185_1","first-page":"3969","article-title":"20 (S)\u2010Ginsenoside Rg3 Promotes Senescence and Apoptosis In Gallbladder Cancer Cells via the p53 Pathway","volume":"9","author":"Zhang F.","year":"2015","journal-title":"Drug Design, Development and Therapy"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02265A"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1546"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5999"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568009614666141128104642"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02902-2"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.70323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.70323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.70323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:31:41Z","timestamp":1782311501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.70323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":189,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ptr.70323"],"URL":"https:\/\/doi.org\/10.1002\/ptr.70323","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}