{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:27:18Z","timestamp":1783452438734,"version":"3.55.0"},"reference-count":73,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Excessive activation of endoplasmic reticulum (ER) stress, chondrocyte apoptosis, and extracellular matrix (ECM) degradation are considered critical pathological factors in OA. However, current therapies are not effective enough to mitigate OA progression. Previous studies reported that gypenosides could suppress chondrocyte injury in human osteoarthritis chondrocytes. However, the mechanisms of these therapeutic effects remain largely elusive. In this study, we focused on the investigation of influences and underlying mechanisms of Gypenoside XVII (GP\u201017), a newly discovered gypenoside monomer extracted from gypenosides in OA. We used tert\u2010butyl hydroperoxide (TBHP) to create an over\u2010accumulation of reactive oxygen species in\u00a0vitro, mimicking oxidative stress\u2010mediated ER stress in OA. We meticulously analyzed parameters such as chondrocyte apoptosis, synthesis and degradation of ECM, and levels of ER stress. Additionally, the X\u2010ray imaging, Safranin O staining, histopathological analysis, immunohistochemical and immunofluorescent staining were assessed to evaluate the protective effect of GP\u201017 on cartilage in\u00a0vivo. Our findings revealed that GP\u201017 effectively mitigated ER stress created by TBHP, subsequently halting chondrocyte apoptosis, as well as preventing ECM degradation. These outcomes were subsequently validated in an in\u00a0vivo model of destabilized medial meniscus (DMM)\u2010induced OA in mice. Notably, the PERK\u2010eIF2\u03b1\u2010CHOP axis shows heightened sensitivity, being suppressed by GP\u201017 at lower concentrations (5 and 10\u2009\u03bcM). Further studies revealed that the effects of GP\u201017 are mediated through downregulation of STING. Our results advocate for the potential use of GP\u201017 as a therapeutic agent in OA treatment.<\/jats:p>","DOI":"10.1002\/ptr.70332","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:20:31Z","timestamp":1777296031000},"page":"4068-4087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gypenoside\n                    <scp>XVII<\/scp>\n                    Ameliorates Osteoarthritis and Suppresses Chondrocyte Apoptosis and Extracellular Matrix Degradation via\n                    <scp>STING<\/scp>\n                    \u2010Dependent Inhibition of\n                    <scp>ER<\/scp>\n                    Stress"],"prefix":"10.1002","volume":"40","author":[{"given":"Jinquan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou Zhejiang 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