{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:22:26Z","timestamp":1783452146982,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474517"],"award-info":[{"award-number":["82474517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH060"],"award-info":[{"award-number":["ZR2024MH060"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Psoriasis is a common chronic immune\u2010mediated inflammatory skin disease that presents significant challenges in clinical management. Gentiopicroside (GPS), a bioactive compound derived from\n                    <jats:italic>Gentiana scabra<\/jats:italic>\n                    , has been reported to possess anti\u2010inflammatory and immunomodulatory properties. However, its potential role in the treatment of psoriasis remains unclear. This study aimed to investigate the therapeutic effects of GPS on psoriasis\u2010like dermatitis and elucidate its underlying mechanisms. A psoriasis\u2010like dermatitis model was established in BALB\/c mice using imiquimod (IMQ). The therapeutic efficacy of GPS was evaluated based on clinical and histopathological improvements. Flow cytometry was used to analyze immune cell populations in the spleen and peripheral blood. In\u00a0vitro, the effects of GPS on bone marrow\u2010derived dendritic cells (BMDCs) were assessed in an inflammatory model. RNA sequencing was performed to identify differentially expressed genes and key signaling pathways in BMDCs after GPS treatment. Molecular docking was employed to predict the binding affinity between GPS and potential targets, which were further validated using Western blotting and immunofluorescence. GPS treatment significantly alleviated psoriasis\u2010like skin lesions in IMQ\u2010induced mice, improving both clinical manifestations and histopathological alterations. GPS reduced the proportions of lymphocytes and dendritic cells and attenuated Th17\u2010driven inflammation, thereby contributing to a more balanced immune milieu. In\u00a0vitro, GPS inhibited the maturation and activation of BMDCs. Transcriptomic profiling demonstrated that GPS modulated multiple immune\u2010 and cytokine\u2010associated pathways, particularly the NF\u2010\u03baB signaling pathway. Molecular docking suggested a strong binding affinity between GPS and NF\u2010\u03baB p65, while Western blotting and immunofluorescence confirmed that GPS suppressed phosphorylated NF\u2010\u03baB p65 nuclear translocation. GPS exerts anti\u2010psoriatic effects through multimodal mechanisms, including immunomodulation and suppression of NF\u2010\u03baB activation. These findings provide experimental evidence and a theoretical basis for the development of GPS as a potential therapeutic agent for psoriasis.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70342","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:46:16Z","timestamp":1778143576000},"page":"4367-4383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gentiopicroside Ameliorates Psoriasis\u2010Like Dermatitis by Modulating Immune Homeostasis and Suppressing\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Activation"],"prefix":"10.1002","volume":"40","author":[{"given":"Lingyun","family":"Du","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Venereology The Second Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Department of Dermatology The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology The Second Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology The Second Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Department of Dermatovenereology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanrong","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology The Second Qilu Hospital of Shandong University  Jinan Shandong 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