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Tea tree oil (TTO) has been explored as a topical treatment for acne, but clinical evidence for its efficacy and safety remain limited and inconsistent. This systematic review and meta\u2010analysis synthesizes available clinical data to evaluate TTO's therapeutic\u00a0effects and safety profile in acne management. PubMed, Embase, and Web of Science were systematically searched for clinical studies published up to August 2025 that evaluated TTO for acne treatment. Study selection, data extraction, and risk\u2010of\u2010bias assessment were independently conducted by trained reviewers. Pooled estimates were calculated using fixed\u2010 or random\u2010effects models according to heterogeneity, quantified using the\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    statistic. Seven studies comprising 445 patients were included. The use of TTO was associated with a reduction in acne severity compared with control groups (pooled odds ratio [pOR]\u2009=\u20090.74, 95% confidence intervals [CI]: 0.63\u20130.88). Adverse events were predominantly local and mild. An exploratory pooled analysis indicated a lower incidence of mild itching with TTO compared to the corresponding control treatments in the included studies (pOR\u2009=\u20090.09, 95% CI: 0.03\u20130.23), with similar trends observed for dryness, burning sensation, erythema, and scaling. Publication bias was not evident based on Egger's test and the trim\u2010and\u2010fill analysis, and overall risk of bias was assessed as low. Current evidence suggests that TTO is associated with a modest reduction in acne severity and generally acceptable short\u2010term tolerability. Larger, high\u2010quality trials with standardized formulations and long\u2010term follow\u2010up are needed to define its clinical role.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70344","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:19:54Z","timestamp":1778210394000},"page":"4444-4453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of\n                    <i>Melaleuca alternifolia<\/i>\n                    (Tea Tree) Oil for Acne\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-0662","authenticated-orcid":false,"given":"Yixin","family":"Ye","sequence":"first","affiliation":[{"name":"School of Public Health and Management Guangxi University of Chinese Medicine  Nanning China"},{"name":"Department of Biological Sciences, Faculty of Science National 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