{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:23:18Z","timestamp":1783452198401,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304147"],"award-info":[{"award-number":["82304147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204145"],"award-info":[{"award-number":["82204145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Macrophages exhibit dynamic functional phenotype shifts under diverse influences, releasing either anti\u2010inflammatory or pro\u2010inflammatory cytokines and playing a pivotal role in ulcerative colitis (UC) pathogenesis. In recent years, the role of enteric glial cells (EGCs) in maintaining intestinal homeostasis has been increasingly recognized. In this study, we investigated whether the alleviation of UC by curcumin is associated with the regulation of EGCs\u2010macrophage interactions, thereby affecting macrophage polarization and its specific mechanisms. Through animal experiments and flow cytometry, we evaluated the efficacy of curcumin in alleviating UC and its impact on macrophages. Furthermore, GDNF intervention confirmed its pivotal role in curcumin's ability to alleviate UC. Finally, molecular docking, cell experiments, laser confocal microscopy, and transmission electron microscopy were employed to elucidate the molecular mechanism. It was found that curcumin can alleviate UC by promoting macrophages' polarization into anti\u2010inflammatory subtypes, increasing the level of glial cell neurotrophic factor (GDNF) in UC mice, and GDNF treatment can alleviate DSS\u2010induced colon injury. Importantly, we demonstrated that GDNF regulates macrophages' polarization by interacting with CK2 to affect the morphological characteristics of macrophage nucleus. The results of this study further enrich the existing pathways for curcumin to alleviate UC and provide new ideas for the prevention and treatment of UC.<\/jats:p>","DOI":"10.1002\/ptr.70345","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:10:33Z","timestamp":1776345033000},"page":"3895-3908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin Induces Macrophages Polarization to Alleviate Ulcerative Colitis by Regulating Macrophage Nuclear Morphology via Affecting the Interaction Between Enteric Glial Cells Glial\u2010Derived Neurotrophic Factor and Casein Kinase 2"],"prefix":"10.1002","volume":"40","author":[{"given":"Huixia","family":"Zhang","sequence":"first","affiliation":[{"name":"Nutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengge","family":"Ren","sequence":"additional","affiliation":[{"name":"Nutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"An","sequence":"additional","affiliation":[{"name":"Nutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziling","family":"Liu","sequence":"additional","affiliation":[{"name":"Nutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College of Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Bai","sequence":"additional","affiliation":[{"name":"Nutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health Shanxi Medical University  Taiyuan China"},{"name":"Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxing","family":"Shi","sequence":"additional","affiliation":[{"name":"Nutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health Shanxi Medical University  Taiyuan China"},{"name":"Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Nutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fubin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Nutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health Shanxi Medical University  Taiyuan China"},{"name":"Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-5946","authenticated-orcid":false,"given":"Shangyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Nutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health Shanxi Medical University  Taiyuan China"},{"name":"Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137272"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2021.0116"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0315-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02108-6"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156144"},{"key":"e_1_2_12_7_1","first-page":"401","article-title":"S100\u2010\u03b2 Aggravates Spinal Cord Injury via Activation of M1 Macrophage Phenotype","volume":"21","author":"Duan K.","year":"2021","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16101504"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1444964"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112230"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42187-5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-024-4101-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.713"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.08.006"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116901"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106288"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.908077"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2024.07.011"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105492"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c00239"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1352946"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105613"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110189"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120261"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041887"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01084"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98541-4"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112943"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6581"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.01.028"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00423-7"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020484"},{"key":"e_1_2_12_34_1","article-title":"Quality of Evidence Supporting the Role of Supplement Curcumin for the Treatment of Ulcerative Colitis: An Overview of Systematic Reviews","volume":"25","author":"Shi H.","year":"2022","journal-title":"Gastroenterology Research and Practice"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102239"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156048"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/21541248.2017.1328303"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.885859"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17300"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-007253"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-024-01022-3"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i7.2195"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.891822"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.896476"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.123775"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1468-6"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-70924-3"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110660"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.028"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.70345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.70345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.70345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:19:06Z","timestamp":1783448346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.70345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/ptr.70345"],"URL":"https:\/\/doi.org\/10.1002\/ptr.70345","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"2025-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}