{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:28:15Z","timestamp":1785558495972,"version":"3.56.0"},"reference-count":292,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of bioactive compounds occurs through eco\u2010sustainable extraction techniques that reduce costs and promote environmental sustainability and public health. Neurodegeneration is a pathological process causing progressive neuronal damage, potentially leading to cell death. Currently, no drug is known to cure neurodegenerative diseases definitively. A balanced diet rich in fruits and vegetables is associated with a lower risk of certain neurodegenerative conditions. The phytochemicals of plants and their beneficial bioactive compounds demonstrate promising therapeutic potential for human neurological diseases, exhibiting antioxidant and anti\u2010inflammatory properties in the brain. This review aims to highlight the currently existing knowledge on the effects of pomegranate peel against neurodegenerative diseases and their mechanisms of action. The manuscript is intended for those who explore strategies for recovering waste materials and for those who investigate the effects of natural products on neurodegeneration. Prospects could include clinical trials in which pomegranate peel is used in the management of human neurodegenerative diseases.<\/jats:p>","DOI":"10.1002\/ptr.70353","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:09:12Z","timestamp":1778605752000},"page":"4588-4610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (\n                    <i>Punica granatum<\/i>\n                    )"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5281-4688","authenticated-orcid":false,"given":"Jessica","family":"Maiuolo","sequence":"first","affiliation":[{"name":"Department of Health Science, Institute of Research for Food Safety &amp; Health (IRC\u2010FSH) University Magna Graecia of Catanzar  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Mazza","sequence":"additional","affiliation":[{"name":"Department of Health Science, Institute of Research for Food Safety &amp; Health (IRC\u2010FSH) University Magna Graecia of Catanzar  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosamaria","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Department of Health Science, Institute of Research for Food Safety &amp; Health (IRC\u2010FSH) University Magna Graecia of Catanzar  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-8987","authenticated-orcid":false,"given":"Francesca","family":"Oppedisano","sequence":"additional","affiliation":[{"name":"Department of Health Science, Institute of Research for Food Safety &amp; Health (IRC\u2010FSH) University Magna Graecia of Catanzar  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Nucera","sequence":"additional","affiliation":[{"name":"Department of Health Science, Institute of Research for Food Safety &amp; Health (IRC\u2010FSH) University Magna Graecia of Catanzar  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Ragusa","sequence":"additional","affiliation":[{"name":"PLANTA\/Research Documentation and Training Center  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ilari","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Quality of Life Promotion San Raffaele University  Rome Italy"},{"name":"Pain Physiology and Pharmacology IRCCS San Raffaele Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Carmela","family":"Passacatini","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Quality of Life Promotion San Raffaele University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tucci","sequence":"additional","affiliation":[{"name":"Department of Health Science, Institute of Research for Food Safety &amp; Health (IRC\u2010FSH) University Magna Graecia of Catanzar  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Trunfio","sequence":"additional","affiliation":[{"name":"Department of Health Science, Institute of Research for Food Safety &amp; Health (IRC\u2010FSH) University Magna Graecia of Catanzar  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Mollace","sequence":"additional","affiliation":[{"name":"Department of Health Science, Institute of Research for Food Safety &amp; Health (IRC\u2010FSH) University Magna Graecia of Catanzar  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Muscoli","sequence":"additional","affiliation":[{"name":"Department of Health Science, Institute of Research for Food Safety &amp; Health (IRC\u2010FSH) University Magna Graecia of Catanzar  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15153456"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.07.006"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2943-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0225"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557517666170208144742"},{"issue":"9","key":"e_1_2_12_7_1","first-page":"834","article-title":"Pomegranate Extract Modulates Processing of Amyloid\u2010\u03b2 Precursor Protein in an Aged Alzheimer's Disease Animal Model","volume":"11","author":"Ahmed A. 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