{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:22:15Z","timestamp":1783452135892,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["26Z9061"],"award-info":[{"award-number":["26Z9061"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003411","name":"Gangneung Asan Hospital","doi-asserted-by":"publisher","award":["2024II0004"],"award-info":[{"award-number":["2024II0004"]}],"id":[{"id":"10.13039\/501100003411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Asthma is a chronic inflammatory disease driven by dysregulated immune responses and mast cell activation. While corticosteroids remain the primary treatment, their long\u2010term use is associated with adverse effects, necessitating safer alternatives. This study aims to evaluate the therapeutic potential and underlying mechanisms of\n                    <jats:italic>Chamaecrista nomame<\/jats:italic>\n                    (CN) extract and its active compound luteolin in allergic asthma. We performed bioactivity\u2010guided fractionation to identify active compounds from CN extract. An ovalbumin\u2010induced murine asthma model was utilized to investigate the efficacy of CN in\u00a0vivo. Transcriptomic analysis of bone marrow\u2010derived mast cells was conducted to elucidate molecular pathways regulated by luteolin. Additionally, cytokine release assays were performed using house dust mite\u2010stimulated human peripheral blood mononuclear cells (PBMCs). CN extract demonstrated potent anti\u2010allergic effects by significantly inhibiting mast cell degranulation and inflammatory mediator release. Luteolin was identified as the primary active compound, modulating Fc\u03b5RI\u2010mediated signaling in mast cells. In the murine asthma model, CN markedly reduced airway inflammation, mucus hypersecretion, and immune cell infiltration, with efficacy comparable to corticosteroids. Transcriptomic data indicated that luteolin suppresses proinflammatory cytokine production by downregulating NF\u2010\u03baB and MAPK signaling pathways. Moreover, CN and luteolin significantly inhibited cytokine release from house dust mite\u2010stimulated human PBMCs, highlighting clinical relevance. These findings suggest that CN and luteolin may serve as promising natural therapeutic agents for allergic asthma, offering a potential alternative to conventional treatments.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70363","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T15:48:44Z","timestamp":1777996124000},"page":"4309-4320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Allergic Potential of\n                    <i>Chamaecrista nomame<\/i>\n                    and Its Compound Luteolin for Novel Asthma Therapy"],"prefix":"10.1002","volume":"40","author":[{"given":"Tae Kyeom","family":"Kang","sequence":"first","affiliation":[{"name":"Center for Natural Product Efficacy Optimization Korea Institute of Science and Technology  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-3040","authenticated-orcid":false,"given":"Myungsuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Natural Product Efficacy Optimization Korea Institute of Science and Technology  Gangneung Republic of Korea"},{"name":"Department of Natural Product Applied Science University of Science and Technology (UST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam Thi","family":"Le","sequence":"additional","affiliation":[{"name":"Center for Natural Product Efficacy Optimization Korea Institute of Science and Technology  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geon","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Natural Product Efficacy Optimization Korea Institute of Science and Technology  Gangneung Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-5890","authenticated-orcid":false,"given":"Wook\u2010Bin","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Natural Product Efficacy Optimization Korea Institute of Science and Technology  Gangneung Republic of Korea"},{"name":"Department of Natural Product Applied Science University of Science and Technology (UST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Jung","sequence":"additional","affiliation":[{"name":"Center for Natural Product Efficacy Optimization Korea Institute of Science and Technology  Gangneung Republic of Korea"},{"name":"Department of Natural Product Applied Science University of Science and Technology (UST)  Daejeon Republic of 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