{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:27:03Z","timestamp":1787066823668,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Curcumin is the main active component of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Curcuma longa<\/jats:italic>\n                    <\/jats:styled-content>\n                    L and has anti\u2010inflammatory, antitumor, and neuroprotective properties, making it a potential candidate for bone cancer pain management. Network pharmacology, molecular docking, and molecular dynamics simulations were used to screen and validate core therapeutic targets of curcumin in bone cancer pain. An in\u00a0vivo mouse model of bone cancer pain was established via intrafemoral injection of Lewis lung cancer cells. A series of in\u00a0vivo assays was conducted to evaluate pain sensitivity, bone microstructure, inflammatory cytokines, pain\u2010related neuropeptides, and protein expression levels. In silico analysis verified that curcumin has a strong binding affinity for JAK1 and STAT3. In\u00a0vivo results demonstrated that curcumin dose\u2010dependently elevated the paw withdrawal threshold and latency, as well as ameliorated bone mineral density and bone destruction. Curcumin also suppressed pro\u2010inflammatory cytokines, substance P, calcitonin gene\u2010related peptides, and inhibited satellite glial cell activation by blocking the JAK1\/STAT3 pathway. Notably, JAK1 agonist (RO8191) co\u2010administration markedly reversed the analgesic effects of curcumin. Curcumin targets the JAK1\/STAT3 signaling pathway, inhibits satellite glial cell activation, downregulates pro\u2010inflammatory cytokine release, and pain\u2010related neuropeptide expression. Therefore, curcumin exerted a significant analgesic effect against bone cancer pain. Elucidating the analgesic mechanism revealed the core therapeutic targets of curcumin in treating bone cancer pain. This study provides experimental evidence for further research on bone cancer pain.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70366","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:15:36Z","timestamp":1778037336000},"page":"4346-4366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin Alleviates Bone Cancer Pain by Inhibiting Satellite Glial Cell Activity via Janus Kinase 1\/Signal Transducer and Transcription 3 Pathway Activator"],"prefix":"10.1002","volume":"40","author":[{"given":"Xinchao","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pain Medicine Suzhou Hospital of Integrated Traditional Chinese and Western Medicine  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Suzhou Hospital of Integrated Traditional Chinese and Western Medicine  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Suzhou Hospital of Integrated Traditional Chinese and Western Medicine  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Suzhou Hospital of Integrated Traditional Chinese and Western Medicine  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Suzhou Hospital of Integrated Traditional Chinese and Western Medicine  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Suzhou Hospital of Integrated Traditional Chinese and Western Medicine  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxue","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Suzhou Hospital of Integrated Traditional Chinese and Western Medicine  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21823"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14010041"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32060309"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11091278"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20231130"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010022\u201003518\u20107"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.31557\/apjcp.2022.23.7.2333"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/10499091221094564"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2023.112004"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041275"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1192714"},{"key":"e_1_2_14_13_1","first-page":"145","article-title":"Evaluation of the Efficacy and Safety of Capsule Longvida and Reg: Optimized Curcumin (Solid Lipid Curcumin Particles) in Knee Osteoarthritis: A Pilot Clinical Study","volume":"12","author":"Gupte P. 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