{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:22:49Z","timestamp":1783452169175,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204697"],"award-info":[{"award-number":["82204697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatocellular carcinoma (HCC) is characterized by a highly immunosuppressive microenvironment, which contributes to its unfavorable clinical outcomes. Myeloid\u2010derived suppressor cells (MDSCs) play a crucial role in this process. Schisandrin B (SchB) shows anti\u2010tumor potential, but its mechanism in suppressing MDSCs remains unclear. This study investigates how SchB inhibits MDSCs accumulation and enhances anti\u2010PD\u20101 therapy efficacy in HCC.SchB's efficacy and mechanism were investigated both in\u00a0vitro and in\u00a0vivo. In\u00a0vitro, MTT, wound healing, EdU, colony formation, flow cytometry, ELISA, western blot, immunofluorescence, Co\u2010IP, molecular dynamics (MD), and CETSA assays were employed to evaluate the therapeutic effects and mechanistic action of SchB on HCC. In\u00a0vivo, a mouse HCC xenograft model was used to evaluate whether SchB could enhance the anti\u2010tumor effect of PD\u20101 mAb and the potential mechanism.Mechanistically, SchB suppressed TRIM27 expression, disrupted the interaction between TRIM27 and STING, and enhanced STING\/TBK1\/IRF3 signaling, thereby suppressing the secretion of IL\u20106 and GM\u2010CSF as well as the accumulation of MDSCs. SchB could directly bind to TRIM27 and downregulate its expression, thereby enhancing STING protein stability. In\u00a0vivo\n                    <jats:italic>,<\/jats:italic>\n                    SchB effectively reduced MDSCs accumulation while promoting T cell recruitment, thereby augmenting the antitumor efficacy of PD\u20101 mAb therapy.SchB up\u2010regulates STING by suppressing TRIM27, inhibits IL\u20106\/GM\u2010CSF secretion, and reduces MDSCs accumulation, indicating that SchB has the potential to be a promising candidate for PD\u20101 inhibitor therapy in HCC.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70368","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:58:08Z","timestamp":1778036288000},"page":"4321-4345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>TRIM27<\/scp>\n                    \/\n                    <scp>STING<\/scp>\n                    Axis Mediates Schisandrin B\u2010Induced Inhibition of Myeloid\u2010Derived Suppressor Cells Accumulation to Potentiate Anti\u2010\n                    <scp>PD<\/scp>\n                    \u20101 Immunotherapy in Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"40","author":[{"given":"Lei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Beihua University  Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Beihua University  Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Beihua University  Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Beihua University  Jilin 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