{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:57:09Z","timestamp":1792461429566,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104481"],"award-info":[{"award-number":["82104481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Astragaloside IV (AS\u2010IV), a primary bioactive component of\n                    <jats:italic>Astragalus membranaceus<\/jats:italic>\n                    (AM). It is very effective in regulating renal diseases. However, the possible underlying mechanism of AS\u2010IV on renoprotection remains unclear. The aim of this study is to find out the regulation mechanism of AS\u2010IV on ischemia\/reperfusion injury\u2010induced Acute kidney injury (IRI\u2010AKI). At first, AS\u2010IV was confirmed to significantly alleviate renal dysfunction, inflammation, and renal tubular epithelial cell apoptosis in IRI\u2010AKI mice. Then, it was found that AS\u2010IV alleviated mitochondrial dysfunction and renal tubular epithelial cell injury induced by IRI. Growing evidence has suggested that PINK1\/Parkin\u2010mediated mitophagy plays a critical protective role in IRI. Based on this, we hypothesized that AS\u2010IV might exert renoprotective effects through activating the PINK1\/Parkin mitophagy pathway. After 3\u2010MA inhibition of autophagy, AS\u2010IV no longer showed its protective effect on HK\u20102 cells in a hypoxic environment. Through further molecular docking, cell thermal migration, and gene targeted silencing experiments, we confirmed that AS\u2010IV activates the PINK1\/Parkin mitophagy pathway and ultimately alleviates IRI\u2010AKI. In summary, all these comprehensive experimental findings indicated that AS\u2010IV can be used as a functional food for the prevention of renal ischemia\/reperfusion injury.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70369","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:45:36Z","timestamp":1778024736000},"page":"4294-4308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Astragaloside\n                    <scp>IV<\/scp>\n                    Enhances Mitophagy to Alleviate Renal Ischemia\/Reperfusion Injury via\n                    <scp>PINK1<\/scp>\n                    \/Parkin Pathway"],"prefix":"10.1002","volume":"40","author":[{"given":"Lin","family":"Liu","sequence":"first","affiliation":[{"name":"Zhejiang Key TCM Laboratory for Chinese Resource Innovation and Transformation, Zhejiang Provincial International S&amp;T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, School of Pharmaceutical Sciences Jinhua Academy of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonghui","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Key TCM Laboratory for Chinese Resource Innovation and Transformation, Zhejiang Provincial International S&amp;T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, School of Pharmaceutical Sciences Jinhua Academy of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujing","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Key TCM Laboratory for Chinese Resource Innovation and Transformation, Zhejiang Provincial International S&amp;T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, School of Pharmaceutical Sciences Jinhua Academy of Zhejiang Chinese 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