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Fucoxanthin (Fx), a marine carotenoid found in brown seaweeds, has various beneficial effects against multiple diseases. However, the potential role of Fx on ALI remains unclear. This study aims to explore the pharmacological potential of Fx in lipopolysaccharide (LPS)\/D\u2010galactosamine (D\u2010Gal)\u2010induced ALI. The therapeutic effect of Fx on ALI was primarily evaluated using a mouse model induced by LPS\/D\u2010Gal, focusing on pathological changes, oxidative stress, inflammation, and pyroptosis. Additionally, the effects of Fx on cell pyroptosis and its molecular mechanisms were explored in an in\u00a0vitro pyroptosis model established by inducing macrophages with LPS\/Nigericin. Fx significantly alleviated the LPS\/D\u2010Gal\u2010induced histopathological progression and hepatocyte apoptosis, reducing plasma levels of ALT, AST, and LDH. It also obviously decreased hepatic MDA levels while increasing antioxidant enzyme activities and GSH concentration compared to LPS\/D\u2010Gal\u2010treated mice. These antioxidant effects were linked to the upregulation of hepatic Nrf\u20102, HO\u20101, and GCLC expression. Furthermore, Fx treatment alleviated macrophage accumulation and downregulated the expression of pro\u2010inflammatory factors in the liver. Importantly, Fx administration suppressed NLRP3 inflammasome\u2010dependent canonical pyroptosis both in LPS\/D\u2010Gal\u2010treated mice and LPS\/Nigericin\u2010stimulated macrophages, potentially mediated by the suppression of MAPKs and NF\u2010\u03baB pathways. These findings suggest that Fx could be an effective strategy to prevent ALI, particularly in cases associated with NLRP3 inflammasome\u2010mediated pyroptosis.<\/jats:p>","DOI":"10.1002\/ptr.70370","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T08:12:46Z","timestamp":1778487166000},"page":"4471-4484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fucoxanthin Protects Against Acute Liver Injury by Inhibiting\n                    <scp>NOD<\/scp>\n                    \u2010Like Receptor Protein 3 Inflammasome\u2010Mediated Pyroptosis Through the Mitogen\u2010Activated Protein Kinases and Nuclear Factor\u2010Kappa B Pathway"],"prefix":"10.1002","volume":"40","author":[{"given":"Yigang","family":"Zheng","sequence":"first","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University  Ningbo 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