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Curcumol, a major bioactive component from\n                    <jats:italic>Curcumae kwangsiensis<\/jats:italic>\n                    , has shown antitumor activity by targeting nucleolin (NCL) and its interaction with ER\u03b136. NCL is an RNA\u2010binding protein that interacts with miR\u2010206, a tumor\u2010suppressive miRNA that inhibits EMT and invasion by regulating target gene expression. However, whether curcumol's effect on BC invasion and migration, as well as the NCL\/ER\u03b136 interaction, is regulated by miR\u2010206 remains unclear. Cell migration and invasion were assessed using wound healing and transwell assays. Dual\u2010luciferase reporter and RIP assays were performed to confirm NCL as a direct target of miR\u2010206. Western blotting and qRT\u2010PCR were used to evaluate protein and miRNA expression. Animal experiments were conducted to explore the inhibitory effect of curcumol on invasion and migration\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    . Curcumol significantly inhibited the invasion and migration of breast cancer cells, while potentiating the inhibitory effects of NCL knockdown on these processes. NCL was identified as a downstream target of miR\u2010206, and curcumol inhibits the invasion and migration of breast cancer cells via downregulating NCL expression and is associated with increased miR\u2010206 levels. Moreover, curcumol inhibits the invasion and migration of breast cancer cells by downregulating the NCL\/ER\u03b136 interaction. The anti\u2010breast cancer effect of curcumol is related to its regulation of the expression of miR\u2010206 and NCL and inhibits the invasion and migration of breast cancer via the miR\u2010206\/NCL\/ER\u03b136 axis.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70375","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:36:37Z","timestamp":1782286597000},"page":"5566-5580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumol Inhibits the Invasion and Migration of Breast Cancer via\n                    <scp>miR<\/scp>\n                    \u2010206\/\n                    <scp>NCL<\/scp>\n                    \/\n                    <scp>ER\u03b136<\/scp>"],"prefix":"10.1002","volume":"40","author":[{"given":"Xiaojuan","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy Guilin Medical University  Guilin People's Republic of 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