{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:20:05Z","timestamp":1790295605661,"version":"4.1.0"},"reference-count":151,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pomegranate (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Punica granatum<\/jats:italic>\n                    <\/jats:styled-content>\n                    L.) is a plant that has been used in traditional medicine for centuries and that has gain popularity in recent years as an anticancer dietary supplement. For the purpose of this review, a comprehensive literature search was performed to gather articles published between 1993 and 2021 and describing the therapeutic potential of pomegranate fruit extracts, juice, and seed oil on breast, colon, and prostate cancer. The results of the studies highlighted the fact that while the consumption of pomegranate has been associated with a number of beneficial effects on cancer, it still remains unclear which chemicals are responsible for such effects. It is hoped that this review will encourage further investigations on pomegranate in order to identify the compounds (or their metabolites) responsible for biological activity and unravel their mode(s) of action at the molecular level.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70382","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:46:10Z","timestamp":1779511570000},"page":"5132-5160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pomegranate in Cancer Therapy: A Review of Anticancer Potential, Mechanisms and Clinical Challenges in Breast, Colon and Prostate Cancers"],"prefix":"10.1002","volume":"40","author":[{"given":"Dusanka","family":"Kitic","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine University of Ni\u0161  Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana","family":"Miladinovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine University of Ni\u0161  Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Randjelovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine University of Ni\u0161  Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-4047","authenticated-orcid":false,"given":"Agnieszka","family":"Szopa","sequence":"additional","affiliation":[{"name":"Department of Medicinal Plant and Mushroom Biotechnology, Faculty of Pharmacy Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Seidel","sequence":"additional","affiliation":[{"name":"Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi\u2010Rad","sequence":"additional","affiliation":[{"name":"Universidad Esp\u00edritu Santo  Samborond\u00f3n Ecuador"},{"name":"Department of Medicine, College of Medicine Korea University  Seoul Republic of Korea"},{"name":"Centro de Estudios Tecnol\u00f3gicos y Universitarios del Golfo  Veracruz Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-0528","authenticated-orcid":false,"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[{"name":"Aromatic Plant Research Center  Lehi Utah USA"},{"name":"Department of Chemistry University of Alabama in Huntsville  Huntsville Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-9116","authenticated-orcid":false,"given":"Daniela","family":"Calina","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Medicine and Pharmacy of Craiova  Craiova Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.21608\/jfds.2023.181435.1089"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf052005r"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940\u20106207.CAPR\u201008\u20100225"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.07.009"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2017.05.010"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2004.7.274"},{"key":"e_1_2_13_8_1","unstructured":"American Cancer Society.2023.\u201cBreast Cancer Statistics | How Common Is Breast Cancer? | American Cancer Society.\u201dhttps:\/\/www.cancer.org\/cancer\/types\/breast\u2010cancer\/about\/how\u2010common\u2010is\u2010breast\u2010cancer.html."},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.6235"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.06.022"},{"key":"e_1_2_13_11_1","unstructured":"ATCC.2023.\u201cCancer Panels | ATCC.\u201dhttps:\/\/www.atcc.org\/cell\u2010products\/human\u2010cells\/cancer\u2010panels#t=productTab&numberOfResults=24."},{"issue":"5","key":"e_1_2_13_12_1","first-page":"1158","article-title":"Evaluation of the Anticancer Activities of Pomegranate (\n                     Punica granatum\n                  ) and Harmal (Rhazya stricta) Plants Grown in Saudi Arabia Heat\u2010Shock Protein Desulfurization of Crude Oil and Oil Products by Local Isolated Bacterial","volume":"4","author":"Awad N. 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