{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:58:42Z","timestamp":1785855522854,"version":"3.56.0"},"reference-count":66,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron\u2010dependent form of regulated non\u2010apoptotic cell death driven by lipid peroxidation. It has emerged as a potential therapeutic target to overcome drug resistance in cancer. Isothiocyanates (ITCs) from cruciferous vegetables have garnered attention for their multi\u2010target anticancer properties. In this review, we present the key mechanisms of ferroptosis and critically evaluate current evidence indicating that ITCs can induce ferroptosis through multiple, compound\u2010specific redox\u2010 and iron\u2010dependent mechanisms. We further discuss whether targeting ferroptosis with ITCs may represent a novel strategy to improve anticancer treatment. Overall, ITCs emerge as versatile but tightly regulated modulators of ferroptosis in cancer, whose effective therapeutic exploitation requires further in\u00a0vivo and clinical studies, biomarker\u2010guided dose optimization, and rational combination strategies with standard anticancer chemotherapy to translate their preclinical findings into therapeutic benefit.<\/jats:p>","DOI":"10.1002\/ptr.70389","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T02:16:20Z","timestamp":1779329780000},"page":"5119-5131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death"],"prefix":"10.1002","volume":"40","author":[{"given":"Valentina","family":"Citi","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Pisa  Pisa Italy"},{"name":"Interdepartmental Research Centre Nutraceuticals and Food for 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