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The emerging viral infections significantly associated with 2019\u2010nCoV have challenged humanity's survival. Further, there is a constant emergence of new resistant viral strains that demand novel antiviral agents with fewer side effects and cell toxicity. Despite significant progress made in immunization and regenerative medicine, numerous viruses still lack prophylactic vaccines and specific antiviral treatments that are so often influenced by the generation of viral escape mutants. Of importance, medicinal herbs offer a wide variety of therapeutic antiviral chemotypes that can inhibit viral replication by preventing viral adsorption, adhering to cell receptors, inhibiting virus penetration in the host cell, and competing for pathways of activation of intracellular signals. The present review will comprehensively summarize the promising antiviral activities of medicinal plants and their bioactive molecules. Furthermore, it will elucidate their mechanism of action and possible implications in the treatment\/prevention of viral diseases even when their mechanism of action is not fully understood, which could serve as the base for the future development of novel or complementary antiviral treatments.<\/jats:p>","DOI":"10.1002\/ptr.7039","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T07:17:46Z","timestamp":1613719066000},"page":"3447-3483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Medicinal plants: Treasure for antiviral drug discovery"],"prefix":"10.1002","volume":"35","author":[{"given":"Sofi Imtiyaz","family":"Ali","sequence":"first","affiliation":[{"name":"Biochemistry &amp; Molecular Biology Lab Division of veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST\u2010K  Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajid Mohammad","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Biochemistry &amp; 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