{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:59:07Z","timestamp":1785855547477,"version":"3.56.0"},"reference-count":66,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003448","name":"General Secretariat for Research and Innovation","doi-asserted-by":"publisher","award":["03427"],"award-info":[{"award-number":["03427"]}],"id":[{"id":"10.13039\/501100003448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. While studies suggest that berry fruits offer beneficial effects in CVD prevention, the bioactive compounds within different berries vary, and the specific mechanisms behind their protective effects are not yet fully elucidated. Our study aimed to evaluate and compare the cardioprotective and anti\u2010atherosclerotic effects of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Morus alba<\/jats:italic>\n                    <\/jats:styled-content>\n                    (white mulberries, WMex) and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vaccinium myrtillus<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. fruit extracts (blueberries, BBex), focusing on acute myocardial infarction (AMI), CVD risk factors, atherosclerosis development, and the underlying mechanisms. WMex and BBex were produced and their qualitative compositions were characterized. We evaluated the infarct size (IS) limiting potential of 8\u2010weeks supplementation with both WMex and BBex at nutritional doses in mice with western diet (WD)\u2010induced metabolic syndrome (MS). We further evaluated atherosclerosis development mitigation after 4\u2010weeks supplementation with the extracts in both male and female WD\u2010fed ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice as well as the putative cardioprotective and atheroprotective mechanisms. The total flavonoids in WMex and BBex were 49.50 and 98.92\u2009mg rutin\/g extract, respectively, while the total phenolic content was 50.74 and 110.00\u2009mg gallic acid\/g extract, respectively. Both extracts limited IS compared to Control by suppressing apoptosis. WMex upregulated endothelial nitric oxide synthase (eNOS) phosphorylation and pathway along with circulating nitrite levels. WMex suppressed the extent of atheromatic area in both male and female ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, while BBex was effective in females without any of the extracts affecting estrogen levels. WMex downregulated NF\u2010kB\u2010ICAM\u20101 axis in the atherosclerotic area and reduced circulating triglyceride levels. None of the extracts caused signs of toxicity, supporting a safety profile. In conclusion, WMex exerts potent cardioprotective and anti\u2010atherosclerotic properties in\u00a0vivo and could be further exploited for CVD prevention.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70391","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:20:46Z","timestamp":1780104046000},"page":"5299-5315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preclinical Evaluation of Berry Extracts as a Nutritional Intervention to Alleviate Myocardial Ischemia\u2013Reperfusion Injury and Atherosclerosis Development"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8394-9272","authenticated-orcid":false,"given":"Lydia","family":"Symeonidi","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota\u2010Efstathia","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"},{"name":"Department of Clinical Therapeutics, Department of Medicine, School of Health Sciences National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Stathopoulos","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriana","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Svouraki","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Efentakis","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Chania","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Choustoulaki","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"},{"name":"Department of Clinical Therapeutics, Department of Medicine, School of Health Sciences National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Xenaki","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Agapaki","sequence":"additional","affiliation":[{"name":"Histochemistry Unit, Biomedical Research Foundation Academy of Athens (BRFAA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsoumani","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-5106","authenticated-orcid":false,"given":"Nikolaos","family":"Kostomitsopoulos","sequence":"additional","affiliation":[{"name":"Centre of Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens (BRFAA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioulia","family":"Tseti","sequence":"additional","affiliation":[{"name":"Uni\u2010Pharma S.A.  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