{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:15:36Z","timestamp":1792178136229,"version":"4.4.0"},"reference-count":141,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Curcumin (diferuloylmethane), a polyphenolic compound, is a component of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Curcuma longa<\/jats:italic>\n                    <\/jats:styled-content>\n                    , commonly known as turmeric. It is well known for its therapeutic properties in a variety of diseases. One of its distinctive mechanisms is epigenetic modification. Epigenetic changes involve alterations in DNA methylation, histone modifications, and non\u2010coding RNA expression patterns, which are interconnected and play a crucial role in various pathologies. It has been shown that curcumin inhibits DNA methyltransferases (DNMT), thereby reversing abnormal hypermethylation and reactivating silenced genes. Concurrently, it downregulates histone deacetylases (HDACs), promotes histone acetyltransferase (HAT) activity, and modulates the expression of non\u2010coding RNAs, including miRNAs. Consequently, curcumin regulates many mechanisms, including inflammatory cascades, oxidative stress responses, and neuronal function. Curcumin's broad\u2010spectrum activity has been demonstrated in various pathologies. For instance, in cancer, it modulates epigenetic mechanisms to support tumor suppression; in neurodegenerative diseases, it enhances neuronal survival; and in metabolic disorders, it improves insulin responsiveness. It also reduces inflammation and fibrosis in cardiovascular, hepatic, renal, and inflammatory conditions. This review will describe curcumin's diverse role as an epigenetic modulator from a novel disease\u2010oriented perspective.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70401","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:58:50Z","timestamp":1783061930000},"page":"5639-5671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin as a Multifaceted Epigenetic Modulator With a Disease\u2010Oriented Perspective"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-033X","authenticated-orcid":false,"given":"Hedieh Sadat","family":"Shamsnia","sequence":"first","affiliation":[{"name":"Department of Toxicology &amp; Pharmacology TeMS.C., Islamic Azad University  Tehran Iran"},{"name":"GI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6614-8298","authenticated-orcid":false,"given":"Mahtab","family":"Roustaei","sequence":"additional","affiliation":[{"name":"Department of Toxicology &amp; 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