{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:21:24Z","timestamp":1788787284429,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["D25020"],"award-info":[{"award-number":["D25020"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["MS[2026]878"],"award-info":[{"award-number":["MS[2026]878"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myocardial hypertrophy represents a maladaptive response in numerous cardiovascular disorders, and potentiating mitophagy has emerged as a potential therapy. Trilobatin (TLB) possesses multiple pharmacological properties, including the alleviation of cardiotoxicity. However, it remains uncertain whether TLB exerts anti\u2010hypertrophic effects or, if so, by what mechanisms. This study was designed to determine whether TLB can attenuate hypertrophy and to elucidate the underlying pathways, focusing on mitophagy. We employed in\u00a0vivo spontaneously hypertensive rats (SHR) and in\u00a0vitro angiotensin II\u2010stimulated cardiomyocytes to evaluate anti\u2010hypertrophic effects. A comprehensive approach was employed, incorporating echocardiography, histological staining, transmission electron microscopy observations, and immunofluorescence to assess phenotypic changes. RNA sequencing, western blotting, immunofluorescence, and ELISA were utilized to elucidate the underlying mechanisms. Additionally, molecular docking, molecular dynamics simulations, and siRNA transfection techniques were applied to identify the target of TLB. The results showed that TLB markedly alleviated hypertrophy in SHR and inhibited angiotensin II\u2010induced cardiomyocyte hypertrophy. Mechanistically, TLB enhanced mitophagy and reduced oxidative stress via activation of the sentrin\u2010specific protease 1\/sirtuin 3 (SENP1\/SIRT3) axis, with direct binding to SENP1. Crucially, SENP1 knockdown abolished TLB's cardioprotective effects, confirming SENP1 as a pivotal mediator. Our findings indicate that TLB exerts anti\u2010hypertrophic effects by promoting mitophagy and suppressing oxidative injury through the SENP1\/SIRT3 axis, highlighting SENP1 as a promising therapeutic target for myocardial hypertrophy.<\/jats:p>","DOI":"10.1002\/ptr.70408","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:29:26Z","timestamp":1781843366000},"page":"5601-5614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trilobatin Ameliorates Myocardial Hypertrophy by Enhancing Mitophagy Through Activation of the Sentrin\u2010Specific Protease 1\/Sirtuin 3 Axis in Spontaneously Hypertensive Rats"],"prefix":"10.1002","volume":"40","author":[{"given":"Ye\u2010li","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi 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