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Thus, more effective therapeutic drugs are imperatively needed to fulfill current unmet medical requirements. Luteoloside, derived from the traditional Chinese medicine\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lonicera japonica<\/jats:italic>\n                    <\/jats:styled-content>\n                    , demonstrates potent anti\u2010tumor activity against solid tumors, but its effects and mechanisms in hematologic malignancies like AML remain unclear. Herein, we found that luteoloside dramatically impaired the proliferation and clonogenic capacity of AML cells and induced cell cycle arrest and reduced the cells at S phase. Furthermore, luteoloside induced apoptosis and promoted differentiation of these cells. Mechanism analysis revealed that luteoloside attenuated \u03b2\u2010catenin in the nucleus, thereby reducing the expression of its downstream effector c\u2010Myc. Activation of Wnt\/\u03b2\u2010catenin signaling by a GSK\u20103\u03b2 inhibitor LiCl reversed the inhibitory effect of luteoloside on AML cell proliferation, apoptosis, and differentiation. Luteoloside significantly reduced the transplantation rate of primary AML cells in a patient\u2010derived xenografts (PDX) model. Combined treatment with luteoloside and cytarabine (Ara\u2010C) showed a synergistic anti\u2010AML effect in\u00a0vitro, and markedly reduced leukemia burden and prolonged the survival in the orthotopic C1498 murine AML model. Collectively, our findings demonstrate that luteoloside suppresses AML cell proliferation, induces apoptosis and differentiation by targeting the \u03b2\u2010catenin\/c\u2010Myc axis, and exhibits synergistic effects with Ara\u2010C. These results underscore its potential as a promising adjunctive therapy for AML.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70416","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:20:28Z","timestamp":1783585228000},"page":"5772-5786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Luteoloside Inhibits the Progression and Enhances Chemosensitivity to Cytarabine in Acute Myeloid Leukemia via \u03b2\u2010Catenin\/c\u2010Myc Axis"],"prefix":"10.1002","volume":"40","author":[{"given":"Xiaofang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Institute of Hematology, Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Wenzhou Key Laboratory of Hematology  Wenzhou Zhejiang 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