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Many IBS patients prefer plant\u2010based preparations to pharmacological therapy; however, the utility of this approach is not well established. To address this issue, a systematic review with meta\u2010analysis to assess the efficacy and safety of plant\u2010based therapy in IBS patients was performed. Literature search with 3 electronic databases (Medline via PubMed, Embase via Ovid, and Web of Science Core Collection) from inception to May 2024. Efficacy was assessed using dichotomous ratings of change in IBS symptoms. A random effects model with 95% confidence intervals was used. Through the screening process, 60 eligible studies were identified (6329 patients). Meta\u2010analysis was performed for fiber (8 studies, RR\u2009=\u20091.22; 95% CI: 1.00\u20131.49), peppermint oil (7 studies, RR\u2009=\u20091.63; 95% CI: 1.33\u20132.00),\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Aloe vera<\/jats:italic>\n                    <\/jats:styled-content>\n                    (3 studies, RR\u2009=\u20091.25; 95% CI: 0.76\u20132.06), and Chinese herbal medicine (7 studies, RR\u2009=\u20091.56; 95% CI: 1.27\u20131.92). For other plant\u2010based substances investigated in at least one randomized controlled trial (RCT) (e.g., St. John's wort, Anise oil), there were insufficient data for a meta\u2010analysis. The quality of many studies was limited. The findings demonstrate that the treatment of IBS patients with peppermint oil and Chinese herbal medicine were more effective than placebo and had a good safety profile. Dietary fiber showed effects that approached significance. Further, well\u2010powered RCTs are needed to establish the place of plant\u2010based preparations in IBS treatment.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70421","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T04:48:40Z","timestamp":1786337320000},"page":"5918-5950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systematic Review and Meta\u2010Analysis: Plant\u2010Based Therapy for Irritable Bowel Syndrome"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7773-3985","authenticated-orcid":false,"given":"Anselm","family":"Meyer","sequence":"first","affiliation":[{"name":"Medical Department II University Hospital, Ludwig Maximilians\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-2936","authenticated-orcid":false,"given":"Jonas","family":"Auer","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Gynaecology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Cascant\u2010Ortolano","sequence":"additional","affiliation":[{"name":"Departmental Library for the University Medical Center Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niclas","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Visceral, Vascular and Endocrine Surgery University Medical Center Halle (Saale), Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Zimmermann\u2010Klemd","sequence":"additional","affiliation":[{"name":"Translational Complementary Medicine, Departement of Pharmaceutical Sciences University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Gr\u00fcndemann","sequence":"additional","affiliation":[{"name":"Translational Complementary Medicine, Departement of Pharmaceutical Sciences University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Busche","sequence":"additional","affiliation":[{"name":"Laboratory and Clinic for Motility Disorders and Functional Digestive Diseases, Department of Integrative Gastroenterology Klinik Arlesheim  Arlesheim Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Schirra","sequence":"additional","affiliation":[{"name":"Medical Department II University Hospital, Ludwig Maximilians\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Fox","sequence":"additional","affiliation":[{"name":"Laboratory and Clinic for Motility Disorders and Functional Digestive Diseases, Department of Integrative Gastroenterology Klinik Arlesheim  Arlesheim Switzerland"},{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"41","article-title":"Chamomile Efficacy in Patients of the Irritable Bowel Syndrome","volume":"7","author":"Agah S.","year":"2015","journal-title":"Der Pharma Chemica"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848211048133"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13860"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"27","article-title":"Efficacy of Peppermint Oil in Diarrhea Predominant IBS\u2013A Double Blind Randomized Placebo\u2013Controlled Study","volume":"22","author":"Alam M. 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