{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:56:47Z","timestamp":1779249407040,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009530","name":"Jawaharlal Institute Of Postgraduate Medical Education and Research","doi-asserted-by":"publisher","award":["Intramural Research Grant (JIPMER\/01\/104\/2018\/007)"],"award-info":[{"award-number":["Intramural Research Grant (JIPMER\/01\/104\/2018\/007)"]}],"id":[{"id":"10.13039\/501100009530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Essential hypertension is an important cause of cardiovascular morbidity and mortality that is compounded by concomitant risk factors like diabetes mellitus and dyslipidemia. <jats:italic>Phyllanthus emblica<\/jats:italic> is a rich source of antioxidants, tannins, and vitamin C and is used in treating various ailments in traditional medicine. This study aimed to elucidate the effects of aqueous extract of <jats:italic>Phyllanthus emblica<\/jats:italic> on essential hypertension and other protective actions. This randomized controlled trial was conducted on 150 patients with essential hypertension. Participants were randomly assigned to receive <jats:italic>Phyllanthus emblica<\/jats:italic> capsule (500\u2009mg) or placebo twice daily, added to their routine medications for 12\u2009weeks. Blood pressure was assessed at baseline, 2, 4, 8, and 12\u2009weeks after beginning treatment or placebo. Other investigations like lipid parameters, oxidant and antioxidant enzyme levels, hs\u2010CRP levels, HbA1C, LFT, RFT, uric acid, and endothelial function were measured at baseline and 12\u2009weeks. Both <jats:italic>Phyllanthus emblica<\/jats:italic> and placebo groups were comparable at baseline. <jats:italic>Phyllanthus emblica<\/jats:italic> had a good safety profile in patients with essential hypertension. However, the treatment with <jats:italic>Phyllanthus emblica<\/jats:italic> failed to produce any additional reduction in systolic and\/or diastolic blood pressure levels and did not exhibit improvement in oxidant status, antioxidant capacity, lipid profile, HbA1C, arterial stiffness parameters, or hs\u2010CRP levels.<\/jats:p>","DOI":"10.1002\/ptr.7043","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T02:21:22Z","timestamp":1613269282000},"page":"3275-3285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Antihypertensive and pleiotropic effects of <i>Phyllanthus emblica<\/i> extract as an add\u2010on therapy in patients with essential hypertension\u2014A randomized double\u2010blind placebo\u2010controlled trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Dayanidhi","family":"Shanmugarajan","sequence":"first","affiliation":[{"name":"Department of Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1777-5120","authenticated-orcid":false,"given":"Chandrashekaran","family":"Girish","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natarajan","family":"Harivenkatesh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bammigatti","family":"Chanaveerappa","sequence":"additional","affiliation":[{"name":"Department of Medicine Jawaharlal Institute of Postgraduate Medical Education and Research  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nakka Chandrasekar","family":"Prasanna Lakshmi","sequence":"additional","affiliation":[{"name":"Directorate of Indian System of Medicine Govt. of Puducherry  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2011.560565"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000065"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.27814"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00090"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-011-9122-2"},{"key":"e_1_2_12_7_1","first-page":"58","volume-title":"The Washington manual of medical therapeutics","author":"Brown A. 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